自体表皮黑素细胞-角质形成细胞悬液移植用于白癜风的细胞治疗：临床评估与生物计量学评价
Transplantation of autologous epidermal melanocyte-keratinocyte cells suspension for cell therapy of vitiligo: A clinical evaluation and biometric assessment.
作者信息
Nilforoushzadeh Mohammad Ali, Farshi Susan, Nouri Maryam, Alavi Shiva, Bayat Tork Batool, Jaffary Fariba, Zare Sona
机构信息
Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Skin Repair Research Center, Jordan Dermatology and Hair Transplantation Center, Tehran, Iran.
出版信息
J Cosmet Dermatol. 2022 Dec;21(12):7147-7152. doi: 10.1111/jocd.15423. Epub 2022 Oct 31.
INTRODUCTION
Among several surgical treatments, the use of transplantation of epidermal cultured melanocytes or melanocytes-keratinocytes cell suspension has gained many researchers and dermatologists' attention as a new technique for the treatment of vitiligo. The present study aimed to transplant autologous epidermal melanocytes-keratinocytes cell suspension for the treatment of vitiligo.
METHODS
In this study, 15 volunteer patients aged between 18 and 45 years old were studied. The autologous melanocytes-keratinocytes cell suspension was then transplanted to the region after dermabrasion. The included patients were evaluated by VisioFace, MPA9, and Skin Scanner-DUB once before and 1, 2, and 6 months after the transplantation, while the extents of stainability and changes in the transplanted region were recorded.
RESULTS
The color contrast between the lesion and normal skin significantly decreased after 1, 2, and 6 months of the melanocytes transplantation compared with the pre-procedure (13.8 ± 0.45 before vs. 12.9 ± 0.43, 12.2 ± 0.45, and 10.2 ± 0.34 at months 1, 2, and 6, p < 0.001). Furthermore, melanin index significantly increased six months after cell transplantation compared to the pretreatment (168.3 ± 4.22 vs. 130.5 ± 3.98, p < 0.001).
CONCLUSION
Transplantation of melanocytes cells with dermabrasion can be effective on vitiligo improvement, so it is recommended.
引言
在几种外科治疗方法中，移植培养的表皮黑素细胞或黑素细胞 - 角质形成细胞悬液作为治疗白癜风的一种新技术，已引起众多研究人员和皮肤科医生的关注。本研究旨在移植自体表皮黑素细胞 - 角质形成细胞悬液治疗白癜风。
方法
本研究纳入了15名年龄在18至45岁之间的志愿者患者。然后将自体黑素细胞 - 角质形成细胞悬液移植到磨皮后的区域。在移植前、移植后1个月、2个月和6个月，使用VisioFace、MPA9和皮肤扫描仪 - DUB对纳入的患者进行评估，同时记录移植区域的染色程度和变化情况。
结果
与术前相比，黑素细胞移植后1个月、2个月和6个月，病变皮肤与正常皮肤之间的颜色对比度显著降低（术前为13.8±0.45，1个月、2个月和6个月时分别为12.9±0.43、12.2±0.45和10.2±0.34，p<0.001）。此外，细胞移植6个月后，黑色素指数与治疗前相比显著增加（168.3±4.22对130.5±3.98，p<0.001）。
结论
磨皮后移植黑素细胞对改善白癜风有效，因此推荐使用。
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