Löntz W, Olsson M J, Moellmann G, Lerner A B
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520-8059.
J Am Acad Dermatol. 1994 Apr;30(4):591-7. doi: 10.1016/s0190-9622(94)70067-2.
Because available treatments for vitiligo generally provide unsatisfactory results, the search for viable therapeutic alternatives continues.
Our purpose was to evaluate several transplantation procedures with cultured autologous melanocytes for their practicality in treating patients with vitiligo.
Twenty-seven patients with stable or active vitiligo were treated after superficial dermabrasion with application of suspensions of autologous cultured melanocytes, melanocyte-keratinocyte mixtures, or epidermal sheets established in vitro.
Regardless of disease activity, use of each method resulted in repigmentation to a similar degree and without scarring in all patients. Melanocyte suspensions offer several advantages: They are easily prepared, can be applied in a controlled manner, permit coverage of large areas, and produce a homogeneous skin color that affords the best cosmetic restoration. The ultrastructure of transplant sites resembled that of uninvolved skin, with one exception: the melanocytes were located slightly higher than in uninvolved skin.
Application of cultured autologous melanocytes to lightly abraded skin is an advantageous addition to the treatments available for patients with vitiligo.
由于现有的白癜风治疗方法通常效果不尽人意，因此仍在继续寻找可行的治疗替代方案。
我们的目的是评估几种自体培养黑素细胞移植程序在治疗白癜风患者中的实用性。
27例稳定期或进展期白癜风患者在浅表磨皮后，应用自体培养黑素细胞悬液、黑素细胞-角质形成细胞混合物或体外构建的表皮片进行治疗。
无论疾病活动程度如何，每种方法的使用都使所有患者的色素沉着程度相似且无瘢痕形成。黑素细胞悬液有几个优点：它们易于制备，可以以可控的方式应用，能够覆盖大面积，并且能产生均匀的肤色，从而提供最佳的美容修复效果。移植部位的超微结构与未受累皮肤相似，但有一个例外：黑素细胞的位置比未受累皮肤略高。
将自体培养黑素细胞应用于轻度磨皮的皮肤是白癜风患者现有治疗方法的一个有益补充。
