Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, Olsztyn, Poland.
Dermatol Ther. 2022 Dec;35(12):e15912. doi: 10.1111/dth.15912. Epub 2022 Oct 17.
Drug-induced gingival overgrowth (DIGO) is an undesirable effect resulting from the therapy of one of the three groups of drugs: phenytoin, calcium channel blockers, and cyclosporine A (CsA). It is caused by a fibrous overgrowth leading to gingivitis, periodontitis, and even tooth loss. Possible consequences include tooth decay worsening, pain and difficulty in eating, bleeding gums, and bad breath. The pathomechanism of the hypertrophy is unknown, but there is a correlation between insufficient oral hygiene and the severity of this phenomenon. The gender and age predilection of gingival hyperplasia as a result of CsA therapy is also noticeable. It is most common in children and adolescents of the male sex. The beneficial effect of the removal of tartar and local irritants in reducing the above symptoms has been demonstrated. One of the treatments for DIGO is conventional gingivectomy. The paper is a review article about cyclosporine-induced gingival hyperplasia.
药物性牙龈增生（DIGO）是由三种药物之一的治疗引起的不良作用：苯妥英钠、钙通道阻滞剂和环孢素 A（CsA）。它是由纤维组织过度生长引起的，导致牙龈炎、牙周炎，甚至牙齿脱落。可能的后果包括龋齿恶化、疼痛和进食困难、牙龈出血和口臭。肥大的发病机制尚不清楚，但口腔卫生不足与这种现象的严重程度之间存在相关性。CsA 治疗引起的牙龈增生的性别和年龄倾向也很明显。它最常见于男性的儿童和青少年。已经证明，清除牙垢和局部刺激物对减轻上述症状有有益作用。DIGO 的治疗方法之一是常规牙龈切除术。本文是一篇关于环孢素诱导的牙龈增生的综述文章。
