Backhouse C M, Lloyd-Davies E R, Shousha S, Burn J I
Br J Surg. 1987 Jul;74(7):591-3. doi: 10.1002/bjs.1800740716.
Breast cancer in young women is an unusual problem which has acquired a poor prognostic reputation in the eyes of many clinicians. We have reviewed all 59 patients with malignant disease of the breast aged 35 years or less managed in the Breast Unit at Charing Cross Hospital between 1974 and 1984. After exclusion of 5 patients (2 with lymphomas, 1 with fibrosarcoma, and 2 with inadequate available data), 54 patients were available for analysis. More than 3 months delay from first symptoms to presentation was seen in 45 per cent and 36 per cent were considered 'late' at initial clinical staging (T3-4, N2-3 or M1). Nevertheless, a 5-year survival of 66 per cent was seen among the 29 patients with sufficient length of follow-up. Distribution among the main histological types was very similar to that found in a consecutive series of 264 breast cancers of all age groups in our unit. We conclude that breast carcinomas in young patients do not significantly differ in type or behaviour from other age groups and that with treatment similar to other premenopausal patients, a prognosis comparable to older patients can be expected.
年轻女性乳腺癌是一个特殊问题,在许多临床医生眼中预后不佳。我们回顾了1974年至1984年间在查令十字医院乳腺科接受治疗的所有59例年龄在35岁及以下的乳腺恶性疾病患者。排除5例患者(2例淋巴瘤、1例纤维肉瘤和2例数据不足者)后,54例患者可供分析。45%的患者从出现首发症状到就诊延迟超过3个月,36%的患者在初始临床分期时被认为是“晚期”(T3 - 4、N2 - 3或M1)。然而,在有足够随访时间的29例患者中,5年生存率为66%。主要组织学类型的分布与我们科室连续收治的264例各年龄段乳腺癌患者的分布非常相似。我们得出结论,年轻患者的乳腺癌在类型或行为上与其他年龄组没有显著差异,并且采用与其他绝经前患者相似的治疗方法,可以预期获得与老年患者相当的预后。