Parkinson's Foundation Centre of Excellence, King's College Hospital NHS Foundation Trust, London, United Kingdom; Department of Psychiatry, Ng Teng Fong General Hospital, Singapore, Singapore; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Parkinson's Foundation Centre of Excellence, King's College Hospital NHS Foundation Trust, London, United Kingdom; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; Department of Neurology, Centre of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Int Rev Neurobiol. 2022;165:283-305. doi: 10.1016/bs.irn.2022.04.003. Epub 2022 May 4.
The Coronavirus Disease 2019 (Covid-19) pandemic and the consequent restrictions imposed worldwide have posed an unprecedented challenge to research and training in Parkinson's disease (PD). The pandemic has caused loss of productivity, reduced access to funding, an oft-acute switch to digital platforms, and changes in daily work protocols, or even redeployment. Frequently, clinical and research appointments were suspended or changed as a solution to limit the risk of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spread and infection, but since the care and research in the field of movement disorders had traditionally been performed at in-person settings, the repercussions of the pandemic have even been more keenly felt in these areas. In this chapter, we review the implications of this impact on neurological research and training, with an emphasis on PD, as well as highlight lessons that can be learnt from how the Covid-19 pandemic has been managed in terms of restrictions in these crucial aspects of the neurosciences. One of the solutions brought to the fore has been to replace the traditional way of performing research and training with remote, and therefore socially distanced, alternatives. However, this has introduced fresh challenges in international collaboration, contingency planning, study prioritization, safety precautions, artificial intelligence, and various forms of digital technology. Nonetheless, in the long-term, these strategies will allow us to mitigate the adverse impact on PD research and training in future crises.
2019 年冠状病毒病(COVID-19)大流行以及随后在全球范围内实施的限制措施,对帕金森病(PD)的研究和培训提出了前所未有的挑战。大流行导致生产力下降,获取资金的机会减少,经常需要快速转向数字平台,以及改变日常工作方案,甚至重新部署。通常,为了限制严重急性呼吸系统综合征冠状病毒 2 型(SARS-CoV-2)传播和感染的风险,临床和研究预约被暂停或更改,但由于运动障碍领域的护理和研究传统上是在面对面的环境中进行的,因此大流行的影响在这些领域更为明显。在本章中,我们回顾了这对神经科学研究和培训的影响,重点是 PD,以及从 COVID-19 大流行在限制神经科学这些关键方面的管理中吸取的经验教训。其中一个解决方案是用远程、因此是保持社交距离的替代方案取代传统的研究和培训方式。然而,这在国际合作、应急计划、研究优先级、安全措施、人工智能和各种形式的数字技术方面带来了新的挑战。尽管如此,从长远来看,这些策略将使我们能够减轻未来危机对 PD 研究和培训的不利影响。