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Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats.

作者信息

Kayser V, Guilbaud G

出版信息

Brain Res. 1981 Dec 7;226(1-2):344-8. doi: 10.1016/0006-8993(81)91110-0.

DOI:10.1016/0006-8993(81)91110-0
PMID:7296298
Abstract

The effects of various i.v. naloxone doses (10 microgram, 300 microgram, 600 microgram, 1 mg/kg) were studied upon vocalization threshold to foot-pressure in 30 normal rats and 70 rats with Freund's adjuvant-induced arthritis. In arthritic rats, the lowest naloxone doses yielded a clear increase in pressure required to trigger vocalization (i.e. were analgesic) while the highest dose (1 mg/kg) was hyperalgesic. In normal rats, naloxone never induced significant changes in the vocalization threshold.

摘要

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