肿瘤微环境与结直肠癌治疗策略的作用。
The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer.
机构信息
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
出版信息
Front Immunol. 2021 Dec 2;12:792691. doi: 10.3389/fimmu.2021.792691. eCollection 2021.
Abstract
Colorectal cancer (CRC) has the second highest mortality rate among all cancers worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment methods have significantly prolonged the survival of patients with CRC. Recently, the emergence of tumor immunotherapy represented by immune checkpoint inhibitors (ICIs) has brought new immunotherapy options for the treatment of advanced CRC. As the efficacy of ICIs is closely related to the tumor immune microenvironment (TME), it is necessary to clarify the relationship between the immune microenvironment of CRC and the efficacy of immunotherapy to ensure that the appropriate drugs are selected. We herein review the latest research progress in the immune microenvironment and strategies related to immunotherapy for CRC. We hope that this review helps in the selection of appropriate treatment strategies for CRC patients.
摘要
结直肠癌（CRC）是全球所有癌症中死亡率第二高的癌症。手术、化疗、放疗、分子靶向等治疗方法显著延长了 CRC 患者的生存时间。最近，以免疫检查点抑制剂（ICIs）为代表的肿瘤免疫疗法的出现为晚期 CRC 的治疗带来了新的免疫治疗选择。由于 ICI 的疗效与肿瘤免疫微环境（TME）密切相关，因此有必要阐明 CRC 的免疫微环境与免疫治疗疗效之间的关系，以确保选择合适的药物。本文综述了结直肠癌免疫微环境及相关免疫治疗策略的最新研究进展。我们希望这篇综述有助于 CRC 患者选择合适的治疗策略。
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