Department of Respiratory Sciences, University of Leicester, Leicester, UK.
Department of Infection and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.
BMC Med. 2022 Oct 10;20(1):386. doi: 10.1186/s12916-022-02588-7.
Regular vaccination against SARS-CoV-2 may be needed to maintain immunity in 'at-risk' populations, which include healthcare workers (HCWs). However, little is known about the proportion of HCWs who might be hesitant about receiving a hypothetical regular SARS-CoV-2 vaccination or the factors associated with this hesitancy.
Cross-sectional analysis of questionnaire data collected as part of UK-REACH, a nationwide, longitudinal cohort study of HCWs. The outcome measure was binary, either a participant indicated they would definitely accept regular SARS-CoV-2 vaccination if recommended or they indicated some degree of hesitancy regarding acceptance (probably accept or less likely). We used logistic regression to identify factors associated with hesitancy for receiving regular vaccination.
A total of 5454 HCWs were included in the analysed cohort, 23.5% of whom were hesitant about regular SARS-CoV-2 vaccination. Black HCWs were more likely to be hesitant than White HCWs (aOR 2.60, 95%CI 1.80-3.72) as were those who reported a previous episode of COVID-19 (1.33, 1.13-1.57 [vs those who tested negative]). Those who received influenza vaccination in the previous two seasons were over five times less likely to report hesitancy for regular SARS-CoV-2 vaccination than those not vaccinated against influenza in either season (0.18, 0.14-0.21). HCWs who trusted official sources of vaccine information (such as NHS or government adverts or websites) were less likely to report hesitancy for a regular vaccination programme. Those who had been exposed to information advocating against vaccination from friends and family were more likely to be hesitant.
In this study, nearly a quarter of UK HCWs were hesitant about receiving a regular SARS-CoV-2 vaccination. We have identified key factors associated with hesitancy for regular SARS-CoV-2 vaccination, which can be used to identify groups of HCWs at the highest risk of vaccine hesitancy and tailor interventions accordingly. Family and friends of HCWs may influence decisions about regular vaccination. This implies that working with HCWs and their social networks to allay concerns about SARS-CoV-2 vaccination could improve uptake in a regular vaccination programme.
ISRCTN Registry, ISRCTN11811602.
为了维持“高危”人群（包括医护人员）的免疫力，可能需要定期接种 SARS-CoV-2 疫苗。然而，人们对医护人员对接种假设性定期 SARS-CoV-2 疫苗可能犹豫不决的比例，以及与这种犹豫相关的因素知之甚少。
对英国-REACH 全国性纵向队列研究中收集的问卷调查数据进行横断面分析。结果测量是二分类的，参与者要么表示如果建议接种，他们肯定会接受定期 SARS-CoV-2 疫苗接种，要么表示对接受疫苗接种有一定程度的犹豫（可能接受或不太可能）。我们使用逻辑回归来确定与定期接种疫苗的犹豫相关的因素。
共纳入分析队列的 5454 名医护人员，其中 23.5%对定期 SARS-CoV-2 疫苗接种犹豫不决。与白人医护人员相比，黑人医护人员更有可能犹豫不决（优势比 2.60，95%CI 1.80-3.72），报告有过 COVID-19 病史的医护人员也是如此（1.33，1.13-1.57[与两次季节性流感疫苗均未接种的医护人员相比]）。在前两个季节接种流感疫苗的医护人员报告对定期 SARS-CoV-2 疫苗接种犹豫不决的可能性比两个季节均未接种流感疫苗的医护人员低五倍以上（0.18，0.14-0.21）。信任疫苗信息官方来源（如 NHS 或政府广告或网站）的医护人员不太可能报告对定期疫苗接种计划的犹豫。那些从朋友和家人那里接触到反对接种疫苗信息的医护人员更有可能犹豫不决。
在这项研究中，近四分之一的英国医护人员对接种定期 SARS-CoV-2 疫苗犹豫不决。我们已经确定了与定期 SARS-CoV-2 疫苗接种犹豫不决相关的关键因素，这些因素可用于识别最有可能对接种犹豫不决的医护人员群体，并相应地调整干预措施。医护人员的朋友和家人可能会影响他们对定期接种疫苗的决定。这意味着与医护人员及其社交网络合作，以消除对 SARS-CoV-2 疫苗接种的担忧，可能会提高定期疫苗接种计划的接种率。
ISRCTN 注册处，ISRCTN83616368。
