Ravinanthanan Manikandan, Hegde Mithra N, Shetty Veena, Kumari Suchetha, Al Qahtani Fahd Nasser
Department of Restorative Dental Sciences, Faculty of Dentistry, Al Baha University, Al Bahah, Saudi Arabia.
Department of Conservative Dentistry and Endodontics, ABSMIDS, NITTE University, Mangalore, Karnataka, India.
Contemp Clin Dent. 2022 Jul-Sep;13(3):205-210. doi: 10.4103/ccd.ccd_360_20. Epub 2022 Sep 24.
Irrigants play an important role in the eradication of microorganisms in the complex root canal system. Sodium hypochlorite (NaOCl), chlorhexidine (CHX), and iodine potassium iodide (IKI) have certain limitations despite their routine clinical use. Surfactant irrigants with antimicrobial properties can be a milestone in endodontics to overcome the drawbacks of conventional irrigants. The aim of this study was to evaluate the antimicrobial efficacy of surfactants in comparison with routine endodontic irrigants on .
Primary irrigants NaOCl, CHX, IKI were prepared at concentrations of 5%, 2.5%, 2%, and 1%; while mixture of tetracycline acid and detergent (MTAD) (100%) served as control group. Surfactants such as cetrimide (CTR) and sodium dodecyl sulfate (SDS) were prepared at concentrations of 0.5%, 1%, and 2%. The direct contact assay was used to evaluate the antimicrobial efficacy after 5 min. Statistical analysis was performed using one-way ANOVA and Mann-Whitney -test.
In the primary group, only 5% CHX was significant over MTAD ( < 0.05). In the surfactant group, all concentrations of CTR and SDS (except 0.5%) were significant ( < 0.05) in killing over MTAD. Two percent CHX in combination with 0.5% CTR and 1% SDS had an effective kill percentage over 2% CHX and MTAD alone.
Surfactant irrigant regimens can be used as adjuncts with CHX to overcome its clinical limitations and potentiate its substantivity, thereby enhancing clinical success in endodontics.
冲洗剂在复杂根管系统中微生物的根除过程中起着重要作用。尽管次氯酸钠（NaOCl）、洗必泰（CHX）和碘化钾（IKI）在临床常规使用，但它们存在一定局限性。具有抗菌特性的表面活性剂冲洗剂可能成为牙髓病学领域克服传统冲洗剂缺点的一个里程碑。本研究的目的是比较表面活性剂与常规牙髓冲洗剂的抗菌效果。
将NaOCl、CHX、IKI这几种主要冲洗剂分别配制成浓度为5%、2.5%、2%和1%的溶液；而四环素酸与洗涤剂的混合物（MTAD）（100%）作为对照组。将西曲溴铵（CTR）和十二烷基硫酸钠（SDS）等表面活性剂分别配制成浓度为0.5%、1%和2%的溶液。采用直接接触试验在5分钟后评估抗菌效果。使用单因素方差分析和曼-惠特尼U检验进行统计分析。
在主要冲洗剂组中，只有5%的CHX比MTAD具有显著差异（P<0.05）。在表面活性剂组中，所有浓度的CTR和SDS（除0.5%外）在杀灭[具体微生物未明确]方面比MTAD具有显著差异（P<0.05）。2%的CHX与0.5%的CTR和1%的SDS联合使用时比单独使用2% CHX和MTAD具有更高的有效杀灭率百分比。
表面活性剂冲洗剂方案可与CHX联合使用，以克服其临床局限性并增强其持续性效应，从而提高牙髓病学的临床成功率。
