Department of Prothesis and Oral and Maxillofacial Surgery, Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego 1235 - Cidade Universitária, Recife, Pernambuco, Zip: 50670-901, Brazil.
Department of Oral Pathology, CHISTHUS University, Fortaleza, CE, Brazil.
Lasers Med Sci. 2022 Dec;37(9):3393-3402. doi: 10.1007/s10103-022-03653-6. Epub 2022 Oct 10.
The objective of this systematic review is to evaluate the effectiveness of low-level laser therapy in the treatment of herpes labialis. The searches were carried out independently by 2 researchers and the articles were selected through the electronic databases according to the inclusion and exclusion criteria previously established. Initially, 480 articles were found, of which 7 randomized clinical trials and 1 clinical trial were selected. In total, 928 patients were included. In the meta-analysis, the mean healing time for laser use was significant, showing a mean reduction of 1.37 [CI 95% = 0.92 to 1.82] days for tissue healing (p < 0.0001). In the meta-analysis to evaluate the time for crust formation, there was no significant difference between the groups and no significant reduction in the mean time for crust formation (p = 0.150). Only one of the selected studies had a low risk of bias. The use of low-level laser proved to be effective in the treatment of herpes labialis. However, due to the high risk of bias in the included studies, there is a need to carry out new standardized studies to prove the effectiveness of this therapy.
本系统评价的目的在于评估低水平激光疗法在治疗唇疱疹方面的有效性。由 2 名研究人员独立进行检索，并根据先前确定的纳入和排除标准，通过电子数据库筛选文章。最初发现了 480 篇文章，其中选择了 7 项随机临床试验和 1 项临床试验。共纳入了 928 名患者。在荟萃分析中，激光治疗的平均愈合时间有显著意义，组织愈合的平均时间减少了 1.37 天[95%CI 为 0.92 至 1.82]（p<0.0001）。在评估结痂形成时间的荟萃分析中，组间无显著差异，结痂形成的平均时间也无显著减少（p=0.150）。仅 1 项入选研究的偏倚风险较低。低水平激光的使用在治疗唇疱疹方面被证明是有效的。然而，由于纳入研究的偏倚风险较高，有必要开展新的标准化研究来证明该疗法的有效性。
