Uberos Jose, Fernandez-Marin Elisabeth, Campos-Martínez Ana, Ruiz-López Aida, García-Serrano Jose Luis
Neonatal Intensive Care Unit, Medicine Faculty, San Cecilio Clinical Hospital, Granada, Spain.
Ophthalmology Service, San Cecilio Clinical Hospital, Granada, Spain.
Acta Ophthalmol. 2023 May;101(3):e294-e301. doi: 10.1111/aos.15269. Epub 2022 Oct 11.
The aim of the study was to assess the influence of blood product transfusions on the development and severity of retinopathy of prematurity (ROP).
A retrospective cohort study was conducted of very low birth weight (VLBW) newborns with less than 32 weeks gestational age (GA) admitted to the neonatal unit of a tertiary care hospital during the period from 1 January 2008 to 31 December 2021. Data on the degree of ROP and the transfusions received were obtained and analysed. Both univariate and multivariate analyses were performed, by logistic regression.
A total of 565 VLBW newborns were recruited, of whom 263 received a red blood cell transfusion prior to 36 weeks corrected GA. The newborns with ROP received significantly more red blood cell transfusions than those not presenting this condition. After adjusting for oxygen therapy and GA, the risk of ROP was found to be 2.77 times higher (95% CI 1.31-5.88) after receiving three or more transfusions, with a 3.95 times higher risk (95% CI 1.40-11.1) of developing severe ROP. Having received the first red blood cell transfusion before 32 weeks corrected GA is associated with an increased risk of ROP (OR 2.18; 95% CI: 1.09-4.36).
In VLBW neonates, the number of red blood cell transfusions and their administration before 32 weeks corrected GA are important risk factors for ROP.
本研究旨在评估血液制品输注对早产儿视网膜病变（ROP）发生发展及严重程度的影响。
对2008年1月1日至2021年12月31日期间入住一家三级护理医院新生儿科的胎龄小于32周的极低出生体重（VLBW）新生儿进行回顾性队列研究。获取并分析ROP程度及所接受输注的数据。通过逻辑回归进行单因素和多因素分析。
共纳入565例VLBW新生儿，其中263例在矫正胎龄36周前接受了红细胞输注。发生ROP的新生儿接受的红细胞输注显著多于未发生该疾病的新生儿。在调整氧疗和胎龄后，发现接受三次或更多次输注后发生ROP的风险高2.77倍（95%可信区间1.31 - 5.88），发生严重ROP的风险高3.95倍（95%可信区间1.40 - 11.1）。在矫正胎龄32周前接受首次红细胞输注与ROP风险增加相关（比值比2.18；95%可信区间：1.09 - 4.36）。
在VLBW新生儿中，红细胞输注次数及其在矫正胎龄32周前的输注是ROP的重要危险因素。
