Uberos Jose, Fernández-Marin Elisabeth, Campos-Martínez Ana, Ruiz-López Aida, García-Serrano Jose Luis
Neonatal Intensive Care Unit, San Cecilio Clinical Hospital, School of Medicine, Granada, Spain.
Ophthalmology Service, San Cecilio Clinical Hospital, Granada, Spain.
Turk Arch Pediatr. 2024 Nov 1;59(6):547-552. doi: 10.5152/TurkArchPediatr.2024.24157.
The objective is to study to what extent the development of retinopathy of prematurity (ROP) is associated with assisted conception (AC) and in vitro fertilization (IVF) in a tertiary referral hospital.
This study is a retrospective observational cohort study. Very-low-birth weight (VLBW) infants with gestational age (GA) <32 weeks or birth weight <1500 g were admitted to the neonatal unit of a tertiary care hospital between January 1, 2011, and December 31, 2021. The study determined the degree of ROP developed according to the type of fertilization used for conception. Main outcome measures were ROP prevalence in pregnancies obtained after IVF/intracytoplasmic sperm injection (ICSI) in the period from January 1, 2011, to December 31, 2021, in a tertiary hospital.
Of the 408 infants included in the study sample, 105 (25.7%) were born following AC and 12.4% of these developed ROP. In our sample, the practice of IVF was not associated with an increase in the incidence of VLBW infants (R2 = 0.12; P = .29).
Conception achieved via AC or IVF is not significantly associated with ROP in any degree of severity.
本研究旨在探讨在一家三级转诊医院中，早产儿视网膜病变（ROP）的发生与辅助受孕（AC）及体外受精（IVF）的关联程度。
本研究为一项回顾性观察队列研究。选取2011年1月1日至2021年12月31日期间入住一家三级护理医院新生儿科的极低出生体重（VLBW）婴儿，其胎龄（GA）<32周或出生体重<1500克。该研究根据受孕所用的受精类型确定ROP的发展程度。主要观察指标为2011年1月1日至2021年12月31日期间在一家三级医院经体外受精/卵胞浆内单精子注射（ICSI）后妊娠的ROP患病率。
在纳入研究样本的408例婴儿中，105例（25.7%）通过AC出生，其中12.4%发生了ROP。在我们的样本中，IVF的实施与VLBW婴儿发病率的增加无关（R2 = 0.12；P = 0.29）。
通过AC或IVF受孕与任何严重程度的ROP均无显著关联。
