Prasad Minali, Dombrovsky David, Christiansen Stephen P, Ingolfsland Ellen C
Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.
Department of Biology Union College Schenectady New York USA.
Pediatr Investig. 2025 Feb 3;9(2):125-132. doi: 10.1002/ped4.12468. eCollection 2025 Jun.
Retinopathy of prematurity (ROP) and anemia are often comorbid in preterm and low birth weight infants in the United States. However, the relationship between ROP and anemia in infants is unclear across prospective and retrospective studies due to confounding from other comorbidities of prematurity and variable study designs. Molecular mechanisms that may underlie this association include tissue hypoxia, oxidative stress, inflammation, and the timing of onset of anemia relative to the phase of ROP. Furthermore, maternal or neonatal disruptions in iron homeostasis, leading to either iron deficiency or accumulation, have been associated with ROP. Further studies, including randomized clinical trials, are needed to better elucidate the association between ROP and anemia, as well as the impact of the timing of the onset of anemia.
在美国，早产儿和低体重儿中，早产儿视网膜病变（ROP）和贫血常常并存。然而，由于早产的其他合并症造成的混杂因素以及研究设计的差异，前瞻性和回顾性研究中关于婴儿ROP与贫血之间的关系尚不清楚。可能构成这种关联基础的分子机制包括组织缺氧、氧化应激、炎症以及贫血相对于ROP阶段的发病时间。此外，母体或新生儿铁稳态的破坏，导致缺铁或铁蓄积，都与ROP有关。需要开展进一步研究，包括随机临床试验，以更好地阐明ROP与贫血之间的关联，以及贫血发病时间的影响。
