POLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
J Magn Reson Imaging. 2023 Jun;57(6):1908-1921. doi: 10.1002/jmri.28470. Epub 2022 Oct 11.
Free-breathing H ventilation MRI shows promise but only single-center validation has yet been performed against methods which directly image lung ventilation in patients with cystic fibrosis (CF).
To investigate the relationship between Xe and H ventilation images using data acquired at two centers.
Sequence comparison.
Center 1; 24 patients with CF (12 female) aged 9-47 years. Center 2; 7 patients with CF (6 female) aged 13-18 years, and 6 healthy controls (6 female) aged 21-31 years. Data were acquired in different patients at each center.
FIELD STRENGTH/SEQUENCE: 1.5 T, 3D steady-state free precession and 2D spoiled gradient echo.
Subjects were scanned with Xe ventilation and H free-breathing MRI and performed pulmonary function tests. Ventilation defect percent (VDP) was calculated using linear binning and images were visually assessed by H.M., L.J.S., and G.J.C. (10, 5, and 8 years' experience).
Correlations and linear regression analyses were performed between Xe VDP, H VDP, FEV , and LCI. Bland-Altman analysis of Xe VDP and H VDP was carried out. Differences in metrics were assessed using one-way ANOVA or Kruskal-Wallis tests.
Xe VDP and H VDP correlated strongly with; each other (r = 0.84), FEV z-score ( Xe VDP r = -0.83, H VDP r = -0.80), and LCI ( Xe VDP r = 0.91, H VDP r = 0.82). Bland-Altman analysis of Xe VDP and H VDP from both centers had a bias of 0.07% and limits of agreement of -16.1% and 16.2%. Linear regression relationships of VDP with FEV were not significantly different between Xe and H VDP (P = 0.08), while Xe VDP had a stronger relationship with LCI than H VDP.
H ventilation MRI shows large-scale agreement with Xe ventilation MRI in CF patients with established lung disease but may be less sensitive to subtle ventilation changes in patients with early-stage lung disease.
2 TECHNICAL EFFICACY: Stage 2.
自由呼吸 H 通气 MRI 显示出很大的潜力，但迄今为止，仅在单中心进行了验证，与直接对囊性纤维化 (CF) 患者的肺通气进行成像的方法相比。
使用在两个中心获得的数据来研究 Xe 和 H 通气图像之间的关系。
序列比较。
中心 1：24 名 CF 患者（12 名女性），年龄 9-47 岁。中心 2：7 名 CF 患者（6 名女性），年龄 13-18 岁，6 名健康对照者（6 名女性），年龄 21-31 岁。每个中心的数据均在不同的患者中采集。
磁场强度/序列：1.5T，3D 稳态自由进动和 2D 扰相梯度回波。
对患者进行 Xe 通气和 H 自由呼吸 MRI 扫描，并进行肺功能测试。使用线性 binning 计算通气缺陷百分比 (VDP)，并由 H.M.、L.J.S. 和 G.J.C.（分别具有 10、5 和 8 年经验）进行视觉评估。
对 Xe VDP、H VDP、FEV 和 LCI 之间进行相关性和线性回归分析。对 Xe VDP 和 H VDP 进行 Bland-Altman 分析。使用单因素方差分析或 Kruskal-Wallis 检验评估指标差异。
Xe VDP 和 H VDP 彼此之间具有很强的相关性（r=0.84），与 FEV z 分数（Xe VDP r=-0.83，H VDP r=-0.80）和 LCI（Xe VDP r=0.91，H VDP r=0.82）相关。来自两个中心的 Xe VDP 和 H VDP 的 Bland-Altman 分析具有 0.07%的偏差，协议区间为-16.1%和 16.2%。Xe 和 H VDP 的 VDP 与 FEV 的线性回归关系没有显著差异（P=0.08），而 Xe VDP 与 LCI 的关系强于 H VDP。
在患有已确立肺部疾病的 CF 患者中，H 通气 MRI 与 Xe 通气 MRI 具有较大的一致性，但对早期肺部疾病患者的细微通气变化可能不太敏感。
2 技术功效：阶段 2。
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