Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Rural Affairs, Key Laboratory of Biotechnology in Plant Protection of Zhejiang Province, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, China.
Department of Horticulture, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, Zhejiang, China.
Crit Rev Food Sci Nutr. 2024;64(11):3220-3234. doi: 10.1080/10408398.2022.2131726. Epub 2022 Oct 11.
Flavonoids are the most abundant polyphenols in plants, and have antioxidant effects as well as other bioactivities (e.g., anti-inflammatory, anti-cancer, anti-allergic, and neuroprotective effects). Vegetables are rich in flavonoids and are indispensable in our daily diet. Moreover, the vegetables as chassis for producing natural products would emerge as a promising means for cost-effective and sustainable production of flavonoids. Understanding the metabolic engineering of flavonoids in vegetables allows us to improve their nutrient composition. In this review, a comprehensive overview of flavonoids in vegetables, including the characterized types and distribution, health-promoting effects, associated metabolic pathways, and applied metabolic engineering are provided. We also introduce breakthroughs in multi-omics approaches that pertain to the elucidation of flavonoids metabolism in vegetables, as well as prospective and potential genome-editing technologies. Based on the varied composition and content of flavonoids among vegetables, dietary suggestions are further provided for human health.
类黄酮是植物中最丰富的多酚，具有抗氧化作用以及其他生物活性（例如，抗炎、抗癌、抗过敏和神经保护作用）。蔬菜富含类黄酮，是我们日常饮食中不可或缺的。此外，蔬菜作为生产天然产物的底盘，将成为一种有前途的方法，用于经济高效和可持续地生产类黄酮。了解蔬菜中类黄酮的代谢工程，可以改善其营养成分。在这篇综述中，我们全面概述了蔬菜中的类黄酮，包括其特征类型和分布、促进健康的作用、相关代谢途径以及应用的代谢工程。我们还介绍了多组学方法的突破，这些方法涉及蔬菜中类黄酮代谢的阐明，以及有前景的和潜在的基因组编辑技术。基于蔬菜中类黄酮的组成和含量的差异，我们进一步为人类健康提供了饮食建议。
