Department of Ophthalmology, Taipei Medical University, Shuang Ho Hospital, New Taipei, Taiwan.
Department of Ophthalmology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Cornea. 2022 Nov 1;41(11):1372-1377. doi: 10.1097/ICO.0000000000002987. Epub 2022 Jan 25.
The purpose of this study was to estimate the longitudinal trend in the incidence of diagnosed dry eye disease (DED) from 2001 to 2015 in Taiwan.
We obtained data from the Taiwan National Health Insurance Research Database that covers 99.9% of Taiwanese residents. The incident DED cases were identified according to diagnoses, drug codes, and procedure codes. We estimated age-specific and sex-specific incidence rates (IRs) between 2001 and 2015.
The annual age-adjusted IRs of DED increased from 0.97 per 1000 in 2001 to 2.52 per 1000 in 2015 among male population and from 2.06 in 2001 per 1000 to 4.91 in 2015 per 1000 among female population. From 2001 to 2015, the annual IRs increased starting from age 20 to 39 years to age 70 to 79 years in both the male and female population. The men in both 20 to 39 and 50 to 59 age groups showed 3-fold higher IRs in 2015 than in 2001. However, the IRs were consistently lower in men than in women from 2001 to 2015. Overall, the IR was highest, between 10.3 (95% confidence interval, 10.1-10.5) and 13.8 (13.5-14.1) per 1000 population, in the population with the highest socioeconomic status.
The IRs of DED increased from 2001 to 2015 for all demographics, particularly in the 20 to 39 and 50 to 59 years aged male population. These findings highlight the disease burden of DED and are expected to grow substantially.
本研究旨在评估 2001 年至 2015 年期间台湾被诊断为干眼病（DED）的发病率的纵向趋势。
我们从涵盖台湾 99.9%居民的台湾全民健康保险研究数据库中获取数据。根据诊断、药物代码和程序代码确定DED 病例。我们估计了 2001 年至 2015 年期间特定年龄和性别的发病率（IR）。
2001 年至 2015 年，男性人群中DED 的年调整年龄特异性发病率从每 1000 人 0.97 例增加到每 1000 人 2.52 例，女性人群中从每 1000 人 2.06 例增加到每 1000 人 4.91 例。从 2001 年到 2015 年，男性和女性人群的发病率从 20 岁至 39 岁开始增加，到 70 岁至 79 岁达到峰值。20 岁至 39 岁和 50 岁至 59 岁的男性人群在 2015 年的发病率是 2001 年的 3 倍。然而，从 2001 年到 2015 年，男性的发病率一直低于女性。总体而言，在社会经济地位最高的人群中，发病率最高，为每 1000 人 10.3（95%置信区间，10.1-10.5）至 13.8（13.5-14.1）例。
所有人群的 DED 发病率从 2001 年到 2015 年都有所增加，特别是在 20 岁至 39 岁和 50 岁至 59 岁的男性人群中。这些发现突显了 DED 的疾病负担，并预计会大幅增加。
