基于大型全年龄段美国医疗保健系统编码分析的干眼疾病估计患病率和发病率。
Estimated Prevalence and Incidence of Dry Eye Disease Based on Coding Analysis of a Large, All-age United States Health Care System.
机构信息
Harvard Medical School, Boston, Massachusetts, USA; Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Naval Medical Research Unit Dayton, Wright Patterson Air Force Base, Ohio, USA; University of Pikeville, Kentucky College of Optometry, Pikeville, Kentucky, USA.
出版信息
Am J Ophthalmol. 2019 Jun;202:47-54. doi: 10.1016/j.ajo.2019.01.026. Epub 2019 Feb 2.
PURPOSE
To assess overall prevalence, annual prevalence, and incidence of dry eye disease (DED) in a large, representative population in the United States.
DESIGN
Prevalence and incidence study.
METHODS
Retrospective analysis using the Department of Defense (DOD) Military Health System (MHS) data on beneficiary medical claims from United States DOD military and civilian facilities, January 1, 2003 through March 31, 2015.
PATIENT POPULATION
Using an algorithm, medical diagnostic codes indicative of DED and prescriptions for cyclosporine ophthalmic emulsion identified a DED population from 9.7 million MHS beneficiaries (DOD service members, retirees, and dependents, aged 2-80+ years).
MAIN OUTCOME MEASURES
DED overall prevalence (2003-2015), annual prevalence (2005-2012), and annual incidence (2008-2012) stratified by sex, age group, and International Statistical Classification of Diseases and Related Health Problems, Ninth Revision diagnosis code grouping.
RESULTS
DED prevalence was 5.28% overall, 7.78% among female beneficiaries, 2.96% among male beneficiaries and increased with age from 0.20% for ages 2-17 years, to 11.66% for individuals aged 50+ years. Annual prevalence increased from 0.8% to 3.0% overall, from 1.4% to 4.5% in female beneficiaries, and from 0.3% to 1.6% in male beneficiaries. Annual prevalence increased across age groups starting at age 18-39, 0.1%-0.6%, to age 50+, 1.8%-6.0%. Annual incidence increased from 0.6% to 0.9% overall, from 0.8% to 1.2% in female beneficiaries, and from 0.3% to 0.6% in male beneficiaries. Across age groups, annual incidence increased starting at age 18-39 (0.2%-0.3%), to age 50+ (1.0%-1.6%).
CONCLUSIONS
DED overall prevalence, annual prevalence, and incidence were found to increase over time for all demographics. These findings highlight the continued importance of research and therapeutic development for this common condition.
目的
评估美国一个大型代表性人群中干眼症（DED）的总体患病率、年患病率和发病率。
设计
患病率和发病率研究。
方法
使用美国国防部（DOD）医疗保健系统（MHS）的受益医疗索赔数据进行回顾性分析，数据来自美国国防部军事和民用设施，时间为 2003 年 1 月 1 日至 2015 年 3 月 31 日。
患者人群
使用一种算法，DED 的医疗诊断代码和环孢素眼用乳液的处方确定了 MHS 受益人群（国防部现役军人、退休人员及其家属，年龄 2-80 岁以上）中的 DED 人群。
主要观察指标
2003-2015 年总体 DED 患病率，2005-2012 年年度患病率，以及按性别、年龄组和国际疾病分类和相关健康问题，第九版诊断代码分组的年度发病率。
结果
DED 总患病率为 5.28%，女性受益人为 7.78%，男性受益人为 2.96%，并随年龄增长而增加，0-17 岁年龄组为 0.20%，50 岁以上年龄组为 11.66%。总体年度患病率从 0.8%增加到 3.0%，女性从 1.4%增加到 4.5%，男性从 0.3%增加到 1.6%。各年龄组的年度患病率从 18-39 岁开始增加，为 0.1%-0.6%，到 50 岁以上为 1.8%-6.0%。总体年度发病率从 0.6%增加到 0.9%，女性从 0.8%增加到 1.2%，男性从 0.3%增加到 0.6%。各年龄组的年度发病率从 18-39 岁开始增加，为 0.2%-0.3%，到 50 岁以上为 1.0%-1.6%。
结论
DED 的总体患病率、年患病率和发病率随着时间的推移都有所增加。这些发现突显了对这种常见疾病进行持续研究和治疗开发的重要性。
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