[儿童龋齿与唾液CCL28及分泌型免疫球蛋白A含量的相关性]
[Correlation between children's dental decay and the contents of saliva CCL28 and secretory immunoglobulin A].
作者信息
Liu Zhi, Que Guoying, Li Jinhuan, Deng Jinxia, Li Lulu, Liu Tingting, Su Da
机构信息
Cener of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Jan;40(1):102-6. doi: 10.11817/j.issn.1672-7347.2015.01.016.
OBJECTIVE
To explore the association of the dental decay of children with the contents of chemokine CCL28 and secretory immunoglobulin A (sIgA) in saliva.
METHODS
A total of 108 children in 2 kindergartens of Changsha, with age from 3 to 5 years old, were enrolled for this study. The saliva was collected from these children when they were in the examination of mouth. Th e children were divided into 3 groups: A non-caries group [dynamical mean-field theory (DMFT)=0], a low caries group (DMFT=1-4) and a high caries group (DMFT ≥ 5). Th e contents of CCL28 and sIgA were measured by ELISA.
RESULTS
The contents of CCL28 and sIgA in saliva were (121.22 ± 32.63) pg/mL and (16.49 ± 8.02) μg/mL, respectively. A positive linear correlation was found between the CCL28 content and sIgA content in saliva (r=0.734). Th e CCL28 and sIgA contents in saliva were positively correlated with the degree of dental caries in children (P<0.05).
CONCLUSION
The dental decay of children leads to the secretion of chemokine CCL28, which promotes the secretion of sIgA in saliva.
目的
探讨儿童龋齿与唾液中趋化因子CCL28及分泌型免疫球蛋白A（sIgA）含量的相关性。
方法
选取长沙市2所幼儿园共108名3至5岁儿童纳入本研究。在这些儿童口腔检查时采集唾液。将儿童分为3组：无龋组[龋失补牙面均数（DMFT）=0]、低龋组（DMFT=1-4）和高龋组（DMFT≥5）。采用酶联免疫吸附测定法（ELISA）检测CCL28和sIgA的含量。
结果
唾液中CCL28和sIgA的含量分别为（121.22±32.63）pg/mL和（16.49±8.02）μg/mL。唾液中CCL28含量与sIgA含量呈正线性相关（r=0.734）。唾液中CCL28和sIgA含量与儿童龋齿程度呈正相关（P<0.05）。
结论
儿童龋齿导致趋化因子CCL28分泌，进而促进唾液中sIgA的分泌。
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