Manoussakis M N, Constantopoulos S H, Gharavi A E, Moutsopoulos H M
Chest. 1987 Sep;92(3):509-13. doi: 10.1378/chest.92.3.509.
The association of clinical and serologic features of 34 patients with systemic sclerosis was examined. Anti-Scl 70 antibody was found to identify patients with abnormal pulmonary function, particularly impaired diffusion (p less than 0.005), as well as patients with digital pitting scars (p less than 0.025). In addition, the presence of digital pitting scars correlated with impaired diffusion (p less than 0.005), suggesting that interstitial pulmonary disease in systemic sclerosis may, like digital pitting, be secondary to vascular pathology. Anticentromere antibody-positive patients were less likely to have abnormalities of pulmonary function (p less than 0.001).
对34例系统性硬化症患者的临床和血清学特征进行了相关性研究。发现抗Scl 70抗体可识别出肺功能异常的患者，尤其是弥散功能受损者（p<0.005），以及有指凹性瘢痕的患者（p<0.025）。此外，指凹性瘢痕的存在与弥散功能受损相关（p<0.005），提示系统性硬化症中的间质性肺病可能与指凹一样，继发于血管病变。抗着丝点抗体阳性的患者肺功能异常的可能性较小（p<0.001）。
