Zhang Jianwei, Das Biswanath, Verho Oscar, Bäckvall Jan-E
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
Department of Medicinal Chemistry, Uppsala Biomedical Center, BMC, Uppsala University, 75236, Uppsala, Sweden.
Angew Chem Int Ed Engl. 2022 Dec 5;61(49):e202212131. doi: 10.1002/anie.202212131. Epub 2022 Nov 4.
Herein, we report an electrochemical oxidative palladium-catalyzed carbonylation-carbocyclization of enallenols to afford γ-lactones and spirolactones, which proceeds with excellent chemoselectivity. Interestingly, electrocatalysis was found to have an accelerating effect on the rate of the tandem process, leading to a more efficient reaction than that under chemical redox conditions.
在此，我们报道了一种电化学氧化钯催化的烯丙醇的羰基化-碳环化反应，可生成γ-内酯和螺内酯，该反应具有优异的化学选择性。有趣的是，发现电催化对串联反应的速率有加速作用，从而使反应比在化学氧化还原条件下更高效。
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