将诊断和药物输送技术转化到资源有限的环境中。
Translating diagnostics and drug delivery technologies to low-resource settings.
机构信息
Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
出版信息
Sci Transl Med. 2022 Oct 12;14(666):eabm1732. doi: 10.1126/scitranslmed.abm1732.
Abstract
Diagnostics and drug delivery technologies engineered for low-resource settings aim to meet their technical design specifications using strategies that are compatible with limited equipment, infrastructure, and operator training. Despite many preclinical successes, very few of these devices have been translated to the clinic. Here, we identify factors that contribute to the clinical success of diagnostics and drug delivery systems for low-resource settings, including the need to engage key stakeholders at an early stage, and provide recommendations for the clinical translation of future medical technologies.
摘要
针对资源匮乏环境设计的诊断和药物输送技术旨在采用与有限的设备、基础设施和操作人员培训相兼容的策略来满足其技术设计规范。尽管有许多临床前的成功案例，但这些设备中很少有被转化为临床应用。在这里，我们确定了有助于诊断和药物输送系统在资源匮乏环境中取得临床成功的因素，包括需要在早期阶段让关键利益相关者参与进来，并为未来医疗技术的临床转化提供建议。
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