视网膜静脉阻塞患者中性粒细胞计数、甘油三酯、单核细胞/高密度脂蛋白比值升高，高密度脂蛋白降低。
Elevated Neutrophil Counts, Triglycerides, Monocyte/High-Density Lipoprotein Ratios, and Lower High-Density Lipoprotein in Patients with Retinal Vein Occlusion.
机构信息
Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, China,
Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, China.
出版信息
Ophthalmic Res. 2023;66(1):265-271. doi: 10.1159/000527446. Epub 2022 Oct 12.
INTRODUCTION
The aim of the study was to evaluate associations of peripheral blood immune cells and blood lipid profile levels with retinal vein occlusion (RVO).
METHODS
This retrospective study included 127 patients with RVO and 108 controls. Patients with RVO were divided into branch RVO (BRVO), central RVO (CRVO), ischemic RVO, or nonischemic RVO groups. Medical records were collected and analyzed.
RESULTS
The RVO group had higher mean neutrophil, triglyceride (TG), and monocyte/high-density lipoprotein (HDL) ratio (MHR) levels and lower HDL levels (p = 0.037, p < 0.001, p = 0.004, and p = 0.002, respectively). TG and MHR levels were significantly higher in the BRVO and CRVO groups compared with the control group (p < 0.001 and p = 0.016, respectively), but there was no difference in BRVO and CRVO group (p = 0.972 and p = 0.916, respectively). Mean HDL levels were significantly lower in the BRVO and CRVO groups than in the control group (p = 0.005), but the difference between the BRVO group and CRVO group was not significant (p = 0.290). Neutrophils, TG, and MHR were independent risk factors for RVO. HDL was an independent protective factor for RVO. Age was an independent risk factor for ischemic RVO.
CONCLUSIONS
Lower HDL, and higher neutrophil, TG, and MHR levels are associated with RVO. Age is an independent risk factor for ischemic RVO.
简介
本研究旨在评估外周血免疫细胞和血脂谱水平与视网膜静脉阻塞（RVO）的关联。
方法
本回顾性研究纳入了 127 例 RVO 患者和 108 例对照者。RVO 患者分为分支 RVO（BRVO）、中央 RVO（CRVO）、缺血性 RVO 和非缺血性 RVO 组。收集并分析病历。
结果
RVO 组的中性粒细胞、甘油三酯（TG）和单核细胞/高密度脂蛋白（HDL）比值（MHR）水平较高，HDL 水平较低（p = 0.037，p < 0.001，p = 0.004 和 p = 0.002）。BRVO 和 CRVO 组的 TG 和 MHR 水平显著高于对照组（p < 0.001 和 p = 0.016），但 BRVO 和 CRVO 组之间无差异（p = 0.972 和 p = 0.916）。BRVO 和 CRVO 组的平均 HDL 水平显著低于对照组（p = 0.005），但 BRVO 组与 CRVO 组之间无显著差异（p = 0.290）。中性粒细胞、TG 和 MHR 是 RVO 的独立危险因素，HDL 是 RVO 的独立保护因素。年龄是缺血性 RVO 的独立危险因素。
结论
较低的 HDL 水平，以及较高的中性粒细胞、TG 和 MHR 水平与 RVO 相关。年龄是缺血性 RVO 的独立危险因素。
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