Wei Qingquan, Luo Liying, Min Yingjun, Gong Yingying, Wang Li
Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Clin Ophthalmol. 2025 Jan 6;19:59-72. doi: 10.2147/OPTH.S500860. eCollection 2025.
The aim of this study was to identify metabolic biomarkers and investigate the metabolic changes associated with aqueous humor in retinal vein occlusion macular edema (RVO-ME).
Aqueous humor (AH) samples were collected from patients, including those diagnosed with central retinal vein occlusion macular edema (CRVO-ME), branch retinal vein occlusion macular edema (BRVO-ME), and a control group undergoing cataract surgery. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized to analyze the metabolomic profiles in aqueous humor.
A total of 28 metabolites were identified as potential biomarkers capable of distinguishing RVO-ME patients from the control group. Of these, 26 metabolites were specific for distinguishing CRVO-ME patients from controls, and 24 metabolites were specific for differentiating BRVO-ME patients from controls. Additionally, 9 metabolites were identified that could differentiate CRVO-ME patients from BRVO-ME patients.
This study successfully identified significant metabolic biomarkers that enhance our understanding of the pathogenesis of RVO-ME. These findings may offer new avenues for the treatment of RVO-ME and aid in differentiating between CRVO-ME and BRVO-ME patients.
本研究旨在识别代谢生物标志物，并研究视网膜静脉阻塞性黄斑水肿（RVO-ME）中与房水相关的代谢变化。
收集患者的房水样本，包括被诊断为中央视网膜静脉阻塞性黄斑水肿（CRVO-ME）、分支视网膜静脉阻塞性黄斑水肿（BRVO-ME）的患者以及接受白内障手术的对照组。采用液相色谱-串联质谱法（LC-MS/MS）分析房水中的代谢组学谱。
共鉴定出28种代谢物作为能够区分RVO-ME患者与对照组的潜在生物标志物。其中，26种代谢物对区分CRVO-ME患者与对照组具有特异性，24种代谢物对区分BRVO-ME患者与对照组具有特异性。此外，还鉴定出9种代谢物可区分CRVO-ME患者与BRVO-ME患者。
本研究成功识别出重要的代谢生物标志物，加深了我们对RVO-ME发病机制的理解。这些发现可能为RVO-ME的治疗提供新途径，并有助于区分CRVO-ME和BRVO-ME患者。
