驱动套细胞淋巴瘤中瓦伯格效应的突变体。
Mutant driving the Warburg Effect in Mantle Cell lymphoma.
作者信息
Kliebhan Johannes, Besse Andrej, Kampa-Schittenhelm Kerstin, Schittenhelm Marcus, Driessen Christoph
机构信息
Department of Oncology and Hematology Cantonal Hospital St Gallen St Gallen Switzerland.
出版信息
Clin Case Rep. 2022 Oct 3;10(10):e6296. doi: 10.1002/ccr3.6296. eCollection 2022 Oct.
Abstract
The p53 mutation R273H in tumor cells leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth, as was previously shown in mice. We here present a patient with mantle cell lymphoma harboring this p53_R273H mutation, whose clinical course is characterized by severe lactic acidosis, hypoglycemia, and aggressive disease.
摘要
肿瘤细胞中的p53突变R273H会导致葡萄糖摄取增加、乳酸酸中毒和肿瘤生长加速，正如先前在小鼠中所显示的那样。我们在此报告一名患有套细胞淋巴瘤且携带这种p53_R273H突变的患者，其临床病程的特征为严重乳酸酸中毒、低血糖和侵袭性疾病。
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