Kliebhan Johannes, Besse Andrej, Kampa-Schittenhelm Kerstin, Schittenhelm Marcus, Driessen Christoph
Department of Oncology and Hematology Cantonal Hospital St Gallen St Gallen Switzerland.
Clin Case Rep. 2022 Oct 3;10(10):e6296. doi: 10.1002/ccr3.6296. eCollection 2022 Oct.
The p53 mutation R273H in tumor cells leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth, as was previously shown in mice. We here present a patient with mantle cell lymphoma harboring this p53_R273H mutation, whose clinical course is characterized by severe lactic acidosis, hypoglycemia, and aggressive disease.
肿瘤细胞中的p53突变R273H会导致葡萄糖摄取增加、乳酸酸中毒和肿瘤生长加速，正如先前在小鼠中所显示的那样。我们在此报告一名患有套细胞淋巴瘤且携带这种p53_R273H突变的患者，其临床病程的特征为严重乳酸酸中毒、低血糖和侵袭性疾病。
