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初诊时单核细胞来源的髓样抑制细胞的外周水平可预测 AML 患者的复发和生存。

Peripheral levels of monocytic myeloid-derived suppressive cells before and after first induction predict relapse and survivals in AML patients.

机构信息

Hematology Department, Nantes University Hospital, Nantes, France.

Hematology Biology, Nantes University Hospital, Nantes, France.

出版信息

J Cell Mol Med. 2022 Nov;26(21):5486-5492. doi: 10.1111/jcmm.17576. Epub 2022 Oct 13.

DOI:10.1111/jcmm.17576
PMID:36226545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9639029/
Abstract

Myeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this monocentric prospective study, 73 adult AML patients, eligible for first-line intensive chemotherapy, were included with the aim to study the influence on long-term outcomes of peripheral blood (PB) levels of monocytic (M) MDSC (M-MDSC) assessed by flow cytometry. A percentage of peripheral M-MDSC higher than 0.55% of leukocytes at diagnosis and a decrease of M-MDSC% after induction came out both as independent negative prognostic factors for leukaemia-free and overall survival.

摘要

髓系来源的抑制细胞（MDSC）能够抑制先天和适应性免疫反应，从而促进实体瘤的进展。然而，关于 MDSC 在急性髓系白血病（AML）中的作用知之甚少。在这项单中心前瞻性研究中，纳入了 73 例适合一线强化化疗的成年 AML 患者，旨在通过流式细胞术评估外周血（PB）单核细胞（M）MDSC（M-MDSC）水平，研究其对长期预后的影响。诊断时外周血 M-MDSC 百分比高于白细胞的 0.55%，诱导后 M-MDSC%下降，这两者都是白血病无复发生存和总生存的独立预后不良因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6916/9639029/a57fde865a78/JCMM-26-5486-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6916/9639029/4d3976327d99/JCMM-26-5486-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6916/9639029/a57fde865a78/JCMM-26-5486-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6916/9639029/4d3976327d99/JCMM-26-5486-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6916/9639029/a57fde865a78/JCMM-26-5486-g001.jpg

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Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy.髓源性抑制细胞在癌症和免疫治疗中的免疫抑制作用。
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