Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan, USA.
School of Medicine, Wayne State University, Detroit, Michigan, USA.
J Neurosci Res. 2023 Jan;101(1):162-171. doi: 10.1002/jnr.25136. Epub 2022 Oct 13.
Cannabis use among pregnant people has increased over the past decade. This is of concern as prenatal cannabis exposure (PCE) is associated with cognitive, motor, and social deficits among offspring. Here, we examined resting-state functional connectivity (rsFC) of the salience network (SN)-a core neurocognitive network that integrates emotional and sensory information-in children with (vs. without) PCE. Using neuroimaging and developmental history data collected from 10,719 children (M ± SD = 9.92 ± 0.62 years; 47.9% female) from the Adolescent Brain Cognitive Development study, we assessed the impact of parent-reported PCE (before or after knowledge of pregnancy) on rsFC within and between the SN and five other core neurocognitive networks. We also evaluated whether SN rsFC mediated the association between PCE and child psychopathology. Results showed that PCE before (but not after) knowledge of pregnancy was associated with lower SN-ventral attention network (VAN) rsFC. Furthermore, psychotic-like experiences mediated the association between PCE and SN-VAN rsFC, and reversal of the model was also significant, such that SN-VAN rsFC mediated the association between PCE and psychotic-like symptoms. However, these mediation effects were no longer significant after the inclusion of covariates. Taken together, these findings suggest that developmental alterations in SN-VAN interactions may explain the previously reported association between PCE and elevated risk of child psychopathology.
在过去的十年中，孕妇的大麻使用量有所增加。这令人担忧，因为产前大麻暴露（PCE）与后代的认知、运动和社交缺陷有关。在这里，我们研究了有（与没有）PCE 的儿童的突显网络（SN）-一个整合情感和感觉信息的核心神经认知网络-的静息状态功能连接（rsFC）。使用来自青少年大脑认知发展研究的 10719 名儿童（M ± SD = 9.92 ± 0.62 岁；47.9%女性）的神经影像学和发育史数据，我们评估了父母报告的 PCE（在知晓怀孕之前或之后）对 SN 内和之间的 rsFC 的影响以及五个其他核心神经认知网络。我们还评估了 SN rsFC 是否介导了 PCE 与儿童精神病理学之间的关联。结果表明，怀孕前（而非怀孕后）的 PCE 与较低的 SN-腹侧注意网络（VAN）rsFC 相关。此外，类精神病体验介导了 PCE 和 SN-VAN rsFC 之间的关联，模型的反转也具有统计学意义，即 SN-VAN rsFC 介导了 PCE 和类精神病症状之间的关联。然而，在纳入协变量后，这些中介效应不再显著。总之，这些发现表明，SN-VAN 相互作用的发育变化可能解释了先前报道的 PCE 与儿童精神病理学风险增加之间的关联。
