College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, People's Republic of China.
College of Chemistry, Fuzhou University, Fuzhou, 350108, People's Republic of China.
J Mater Chem B. 2022 Oct 26;10(41):8375-8385. doi: 10.1039/d2tb01591a.
Myocardial infarction (MI) is the leading cause of cardiovascular disease-related deaths. Local ischemia and cardiomyocyte death lead to a series of pathological remodeling events of the infarcted extracellular matrix (ECM) that are significantly different from normal cardiac tissues. These pathological characteristics have inspired the development of microenvironment-responsive therapeutic strategies for MI. Bioactive hydrogels attract great attention because of their unique physicochemical features to induce specific biological responses upon interacting with cells, ECMs, and signal molecules. They exhibit physicochemical-responsive activities to regulate interactions between hydrogels and the biological system. Many bioactive hydrogels with intelligent properties have been used to repair infarcted myocardium and restore the cardiac function after MI. Current research studies ensure that bioactive hydrogels have a high clinical importance and application prospects. This review summarizes the advances of bioactive hydrogels in the field of on-demand treatment of MI and evaluates their key physicochemical characteristics. A range of bioactive hydrogels and their biomedical applications are discussed in repairing injured hearts and restoring cardiac functions, providing insights into the development of intelligent therapeutic approaches for MI.
心肌梗死（MI）是心血管疾病相关死亡的主要原因。局部缺血和心肌细胞死亡导致梗死细胞外基质（ECM）的一系列病理重塑事件，这些事件与正常心脏组织显著不同。这些病理特征激发了针对 MI 的微环境响应治疗策略的发展。生物活性水凝胶因其独特的物理化学特性而受到极大关注，这些特性在与细胞、ECM 和信号分子相互作用时会诱导特定的生物学反应。它们表现出物理化学响应活性，以调节水凝胶与生物系统之间的相互作用。许多具有智能特性的生物活性水凝胶已被用于修复梗死心肌并恢复 MI 后的心脏功能。目前的研究确保了生物活性水凝胶具有很高的临床重要性和应用前景。本综述总结了生物活性水凝胶在 MI 按需治疗领域的进展，并评估了它们的关键物理化学特性。讨论了一系列生物活性水凝胶及其在修复受损心脏和恢复心脏功能方面的生物医学应用，为 MI 的智能治疗方法的发展提供了新的见解。
