Richtsmeier Devon, O'Connell Jericho, Rodesch Pierre-Antoine, Iniewski Kris, Bazalova-Carter Magdalena
Department of Physics and Astronomy, University of Victoria, Victoria, British Columbia, Canada.
Redlen Technologies, Saanichton, British Columbia, Canada.
Med Phys. 2023 Jan;50(1):380-396. doi: 10.1002/mp.16049. Epub 2022 Oct 22.
Metal artifacts have been an outstanding issue in computed tomography (CT) since its first uses in the clinic and continue to interfere. Metal artifact reduction (MAR) methods continue to be proposed and photon-counting detectors (PCDs) have recently been the subject of research toward this purpose. PCDs offer the ability to distinguish the energy of incident x-rays and sort them in a set number of energy bins. High-energy data captured using PCDs have been shown to reduce metal artifacts in reconstructions due to reduced beam hardening.
High-energy reconstructions using PCD-CT have their drawbacks, such as reduced image contrast and increased noise. Here, we demonstrate a MAR algorithm, trace replacement MAR (TRMAR), in which the data corrupted by metal artifacts in full energy spectrum projections are corrected using the high-energy data captured during the same scan. The resulting reconstructions offer similar MAR to that seen in high-energy reconstructions, but with improved image quality.
Experimental data were collected using a bench-top PCD-CT system with a cadmium zinc telluride PCD. Simulations were performed to determine the optimal high-energy threshold and to test TRMAR in simulations using the XCAT phantom and a biological sample. For experiments a 100-mm diameter cylindrical phantom containing vials of water, two screws, various densities of Ca(ClO ) , and a spatial resolution phantom was imaged with and without the screws. The screws were segmented in the initial reconstruction and forward projected to identify them in the sinogram space in order to perform TRMAR. The resulting reconstructions were compared to the control and to reconstructions corrected using normalized metal artifact reduction (NMAR). Additionally, a beef short rib was imaged with and without metal to provide a more realistic phantom.
XCAT simulations showed a reduction in the streak artifact from -978 HU in uncorrected images to -10 HU with TRMAR. The magnitude of the metal artifact in uncorrected images of the 100-mm phantom was -442 HU, compared to the desired -81 HU with no metal. TRMAR reduced the magnitude of the artifact to -142 HU, with NMAR reducing the magnitude to -96 HU. Relative image noise was reduced from 176% in the high-energy image to 56% using TRMAR. Density quantification was better with NMAR, with the Ca(ClO ) vial affected most by metal artifacts showing 0.8% error compared to 2.1% with TRMAR. Small features were preserved to a greater extent with TRMAR, with the limiting spatial frequency at 20% of the MTF fully maintained at 1.31 lp/mm, while with NMAR it was reduced to 1.22 lp/mm. Images of the beef short rib showed better delineation of the shape of the metal using TRMAR.
NMAR offers slightly better performance compared to TRMAR in streak reduction and image quality metrics. However, TRMAR is less susceptible to metal segmentation errors and can closely approximate the reduction in the streak metal artifact seen in NMAR at 1/3 the computation time. With the recent introduction of PCD-CT into the clinic, TRMAR offers notable potential for fast, effective MAR.
自计算机断层扫描(CT)首次应用于临床以来,金属伪影一直是一个突出问题,且仍在造成干扰。金属伪影减少(MAR)方法不断被提出,光子计数探测器(PCD)最近成为了这方面研究的对象。PCD能够区分入射X射线的能量,并将它们分类到一定数量的能量 bins 中。已表明,使用PCD捕获的高能数据可减少重建过程中的金属伪影,这是由于束硬化现象减少。
使用PCD-CT进行的高能重建存在缺点,如图像对比度降低和噪声增加。在此,我们展示了一种MAR算法,即迹线替换MAR(TRMAR),其中在全能量谱投影中被金属伪影破坏的数据,使用在同一次扫描中捕获的高能数据进行校正。由此得到的重建结果与高能重建中的MAR效果相似,但图像质量有所改善。
使用配备碲化镉锌PCD的台式PCD-CT系统收集实验数据。进行模拟以确定最佳高能阈值,并在使用XCAT体模和生物样本的模拟中测试TRMAR。在实验中,对一个直径100毫米的圆柱形体模进行成像,该体模包含水瓶、两个螺丝、各种密度的Ca(ClO) 以及一个空间分辨率体模,成像时分别有螺丝和没有螺丝的情况。在初始重建中对螺丝进行分割,并向前投影以在正弦图空间中识别它们,以便执行TRMAR。将得到的重建结果与对照以及使用归一化金属伪影减少(NMAR)校正的重建结果进行比较。此外,对一块带骨牛小排进行成像,成像时分别有金属和没有金属的情况,以提供更逼真的体模。
XCAT模拟显示,未校正图像中的条纹伪影从 -978 HU减少到使用TRMAR时的 -10 HU。100毫米体模未校正图像中的金属伪影幅度为 -442 HU,相比之下,无金属时所需的幅度为 -81 HU。TRMAR将伪影幅度降低到 -142 HU,NMAR将幅度降低到 -96 HU。相对图像噪声从高能图像中的176%降低到使用TRMAR时的56%。密度定量方面,NMAR表现更好,受金属伪影影响最大的Ca(ClO) 瓶,与TRMAR时的2.1%误差相比,NMAR时的误差为0.8%。使用TRMAR时,小特征得到了更大程度的保留,调制传递函数(MTF)20%处的极限空间频率在1.31 lp/mm时完全得以维持,而使用NMAR时则降至1.22 lp/mm。带骨牛小排的图像显示,使用TRMAR时对金属形状的描绘更好。
在条纹减少和图像质量指标方面,NMAR的性能略优于TRMAR。然而,TRMAR对金属分割误差的敏感度较低,并且在计算时间仅为NMAR三分之一的情况下,能够接近NMAR中条纹金属伪影的减少程度。随着PCD-CT最近引入临床,TRMAR在快速、有效MAR方面具有显著潜力。