蓝光介导、无光催化剂的杂芳基亚磺酰亚胺的脱羧烷基化反应。
Blue Light-Mediated, Photocatalyst-Free Decarboxylative Alkylation of Heteroaryl Sulfinimines.
机构信息
Discovery Process Research, Janssen Research & Development LLC, 3210 Merryfield Row, San Diego, California 92121, United States.
Discovery Chemistry, Janssen Research & Development LLC, 3210 Merryfield Row, San Diego, California 92121, United States.
出版信息
J Org Chem. 2022 Nov 4;87(21):14948-14952. doi: 10.1021/acs.joc.2c01861. Epub 2022 Oct 13.
We report a diastereoselective, photocatalyst-free decarboxylative alkylation of (hetero)aryl sulfinimines using redox-active esters under blue light. High yields and diastereoselectivities can be achieved under mild conditions, and we demonstrate its utility as a synthetic method, especially for medicinal chemists.
我们报告了在蓝光下使用氧化还原活性酯实现（杂）芳基亚磺亚胺的非对映选择性、无光催化剂脱羧烷基化。在温和条件下可以实现高产率和高非对映选择性，我们证明了它作为一种合成方法的实用性，特别是对于药物化学家。
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