Health Sciences University, Sultangazi Haseki Training and Research Hospital, Department of Cardiology - Istanbul, Turkey.
Health Sciences University, Sultan Abdülhamid Han Training and Research Hospital, Department of Cardiology - Istanbul, Turkey.
Rev Assoc Med Bras (1992). 2022 Sep;68(9):1297-1302. doi: 10.1590/1806-9282.20220410.
The purpose of this study was to explore the efficacy of the triglyceride glucose (TyG) index on in-hospital mortality in nondiabetic coronavirus disease 2019 (COVID-19) patients with myocardial injury.
This was a retrospective study, which included 218 nondiabetic COVID-19 patients who had myocardial injury. The TyG index was derived using the following equation: log [serum triglycerides (mg/dL) ×fasting blood glucose (mg/dL)/2].
Overall, 49 (22.4%) patients died during hospitalization. Patients who did not survive had a higher TyG index than survivors. In multivariate Cox regression analysis, it was found that the TyG index was independently associated with in-hospital death. A TyG index cutoff value greater than 4.97 was predicted in-hospital death in nondiabetic COVID-19 patients with myocardial damage, with 82% sensitivity and 66% specificity. A pairwise evaluation of receiver operating characteristic (ROC) curves demonstrated that the TyG index (AUC: 0.786) had higher discriminatory performance than both triglyceride (AUC: 0.738) and fasting blood glucose (AUC: 0.660) in predicting in-hospital mortality among these patients.
The TyG index might be used to identify high-risk nondiabetic COVID-19 patients with myocardial damage.
本研究旨在探讨三酰甘油葡萄糖（TyG）指数对非糖尿病 2019 冠状病毒病（COVID-19）合并心肌损伤患者住院期间死亡率的预测价值。
这是一项回顾性研究，纳入了 218 例非糖尿病 COVID-19 合并心肌损伤患者。TyG 指数通过以下公式计算得出：log[血清三酰甘油（mg/dL）×空腹血糖（mg/dL）/2]。
共有 49 例（22.4%）患者在住院期间死亡。未存活患者的 TyG 指数高于存活患者。多因素 Cox 回归分析发现，TyG 指数与住院期间死亡独立相关。TyG 指数大于 4.97 预测非糖尿病 COVID-19 合并心肌损伤患者住院期间死亡的截断值，其敏感性为 82%，特异性为 66%。受试者工作特征（ROC）曲线的两两比较显示，TyG 指数（AUC：0.786）在预测这些患者住院期间死亡率方面的区分性能优于三酰甘油（AUC：0.738）和空腹血糖（AUC：0.660）。
TyG 指数可用于识别合并心肌损伤的非糖尿病 COVID-19 高危患者。
