Vitreous Retina Macula Consultants of New York, New York, New York.
Vitreous Retina Macula Consultants of New York, New York, New York; NMS Research, NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal.
Ophthalmol Retina. 2023 Apr;7(4):346-353. doi: 10.1016/j.oret.2022.10.001. Epub 2022 Oct 10.
To investigate whether noninvasive en face ultrawidefield (UWF) OCT can demonstrate salient features of the choroidal vasculature in eyes with central serous chorioretinopathy (CSC).
Retrospective observational case series.
Patients diagnosed with CSC who underwent UWF indocyanine green angiography (ICGA) and widefield OCT imaging were included.
Widefield OCT imaging was performed with a horizontal 23-mm × vertical 20-mm field of view of 5 visual fixations (1 central and 4 peripheral fixations) to compose structural en face UWF OCT montage images and UWF choroidal thickness maps. Automated image alignment was performed before grading.
A comparison of choroidal vascular findings seen with UWF ICGA and en face UWF OCT images, including size and distribution of choroidal venous drainage areas and identification of dilated choroidal veins (pachyvessels) crossing the physiologic choroidal watershed zones. The spatial correlation between choroidal vascular hyperpermeability on UWF ICGA images and areas of choroidal thickening on UWF choroidal thickness maps was determined.
Forty-two eyes from 27 patients with CSC with a mean age of 56 ± 12 years (range, 31-77 years) were included. Quantitative measures of vortex vein drainage areas on en face UWF OCT images were significantly and positively correlated with those obtained with UWF ICGA (mean Pearson r = 0.825, P < 0.01). Identification of pachyvessels crossing the choroidal watershed zones showed an excellent correlation between UWF ICGA and en face UWF OCT images (mean Spearman ρ = 0.873, P < 0.01). In all cases, choroidal vascular hyperpermeability was observed on UWF ICGA spatially colocalized with areas of choroidal thickening on the UWF choroidal thickness map. Congestion within the entire drainage area of the dominant vortex systems was observed on UWF choroidal thickness maps.
In eyes with CSC, noninvasive en face UWF OCT imaging can show distinctive features of choroidal venous insufficiency previously identified with UWF ICGA. Ultrawidefield OCT choroidal thickness maps enable quantitative assessment of choroidal congestion.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
研究非侵入性的眼前节超广角（UWF）OCT 是否可以显示中心性浆液性脉络膜视网膜病变（CSC）患者脉络膜血管的显著特征。
回顾性观察性病例系列。
纳入接受 UWF 吲哚青绿血管造影（ICGA）和宽视野 OCT 成像诊断为 CSC 的患者。
使用水平 23mm×垂直 20mm 的 5 个视固视点（1 个中央和 4 个周边固视点）进行宽视野 OCT 成像，以组合结构眼前节 UWF OCT 蒙片图像和 UWF 脉络膜厚度图。在分级之前进行自动图像配准。
比较 UWF ICGA 和眼前节 UWF OCT 图像中观察到的脉络膜血管发现，包括脉络膜静脉引流区的大小和分布，以及识别穿过生理性脉络膜分水岭区的扩张脉络膜静脉（厚壁血管）。确定 UWF ICGA 图像上脉络膜血管通透性与 UWF 脉络膜厚度图上脉络膜增厚区之间的空间相关性。
纳入 27 例 CSC 患者的 42 只眼，平均年龄 56±12 岁（范围，31-77 岁）。UWF OCT 图像上涡静脉引流区的定量测量与 UWF ICGA 获得的定量测量明显正相关（平均 Pearson r=0.825，P<0.01）。识别穿过脉络膜分水岭区的厚壁血管显示 UWF ICGA 和眼前节 UWF OCT 图像之间具有极好的相关性（平均 Spearman ρ=0.873，P<0.01）。在所有情况下，UWF ICGA 上观察到的脉络膜血管通透性与 UWF 脉络膜厚度图上的脉络膜增厚区在空间上是一致的。在 UWF 脉络膜厚度图上，观察到主导涡系统的整个引流区充血。
在 CSC 眼中，非侵入性的眼前节超广角 OCT 成像可以显示以前通过 UWF ICGA 识别的脉络膜静脉功能不全的独特特征。超广角 OCT 脉络膜厚度图可用于定量评估脉络膜充血。
参考文献后可能会发现专有或商业披露。
