State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Cell Prolif. 2023 Jan;56(1):e13346. doi: 10.1111/cpr.13346. Epub 2022 Oct 13.
Liver cancer is one of the common malignancies. The dysregulation of metabolism is a driver of accelerated tumourigenesis. Metabolic changes are well documented to maintain tumour growth, proliferation and survival. Recently, a variety of polyphenols have been shown to have a crucial role both in liver disease prevention and metabolism regulation.
We conducted a literature search and combined recent data with systematic analysis to comprehensively describe the molecular mechanisms that link polyphenols to metabolic regulation and their contribution in liver protection and liver cancer prevention.
Targeting metabolic dysregulation in organisms prevents and resists the development of liver cancer, which has important implications for identifying new therapeutic strategies for the management and treatment of cancer. Polyphenols are a class of complex compounds composed of multiple phenolic hydroxyl groups and are the main active ingredients of many natural plants. They mediate a broad spectrum of biological and pharmacological functions containing complex lipid metabolism, glucose metabolism, iron metabolism, intestinal flora imbalance, as well as the direct interaction of their metabolites with key cell-signalling proteins. A large number of studies have found that polyphenols affect the metabolism of organisms by interfering with a variety of intracellular signals, thereby protecting the liver and reducing the risk of liver cancer.
This review systematically illustrates that various polyphenols, including resveratrol, chlorogenic acid, caffeic acid, dihydromyricetin, quercetin, catechins, curcumin, etc., improve metabolic disorders through direct or indirect pathways to protect the liver and fight liver cancer.
肝癌是常见的恶性肿瘤之一。代谢失调是肿瘤加速发生的驱动因素。代谢变化被充分证明可维持肿瘤生长、增殖和存活。最近，多种多酚被证明在肝脏疾病预防和代谢调节中具有关键作用。
我们进行了文献检索，并结合最新数据进行了系统分析，全面描述了多酚与代谢调节之间的分子机制及其在肝脏保护和肝癌预防中的作用。
针对生物体内的代谢失调可预防和抵抗肝癌的发生，这对于确定癌症管理和治疗的新治疗策略具有重要意义。多酚是一类由多个酚羟基组成的复杂化合物，是许多天然植物的主要活性成分。它们介导广泛的生物和药理功能，包含复杂的脂质代谢、葡萄糖代谢、铁代谢、肠道菌群失衡，以及其代谢物与关键细胞信号蛋白的直接相互作用。大量研究发现，多酚通过干扰多种细胞内信号来影响生物体的代谢，从而保护肝脏并降低肝癌风险。
本综述系统地阐明了各种多酚，包括白藜芦醇、绿原酸、咖啡酸、二氢杨梅素、槲皮素、儿茶素、姜黄素等，通过直接或间接途径改善代谢紊乱，保护肝脏，防治肝癌。
