School of Traditional Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Lipids Health Dis. 2022 Oct 13;21(1):101. doi: 10.1186/s12944-022-01701-2.
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction. Endothelial cell function is closely related to sphingolipid metabolism, and normal sphingolipid metabolism is critical for maintaining endothelial cell homeostasis. Sphingolipid metabolites or key enzymes in abnormal situation, including sphingosine, ceramide (Cer), sphingosine-1-phosphate (S1P), serine, sphingosine kinase (SPHK), ceramide kinase (Cerk), sphingosine-1-phosphate lyase (S1PL) etc., may have a protective or damaging effect on the function of endothelial cells. This review summarizes the effects of sphingolipid metabolites and key enzymes disordering in sphingolipid metabolism on endothelial cells, offering some insights into further research on the pathogenesis of cardiovascular diseases and corresponding therapeutic targets.
许多心血管疾病，包括动脉粥样硬化、高血压、冠心病、糖尿病等，其特征是内皮细胞功能障碍。内皮细胞功能与鞘脂代谢密切相关，正常的鞘脂代谢对于维持内皮细胞的内稳态至关重要。鞘脂代谢物或异常情况下的关键酶，包括神经酰胺（Cer）、鞘氨醇（Sph）、鞘氨醇-1-磷酸（S1P）、丝氨酸、鞘氨醇激酶（SPHK）、神经酰胺激酶（Cerk）、鞘氨醇-1-磷酸酶（S1PL）等，可能对内皮细胞的功能具有保护或损害作用。本文综述了鞘脂代谢物和关键酶紊乱对内皮细胞的影响，为进一步研究心血管疾病的发病机制和相应的治疗靶点提供了一些见解。
