Emam Omnia, Wasfey Eman F, Hamdy Nadia M
Egyptian Drug Authority, Cairo, Egypt.
Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Cancer Cell Int. 2022 Oct 13;22(1):316. doi: 10.1186/s12935-022-02736-2.
Colorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking the 2nd cause of cancer-related fatality worldwide. The worldwide burden of CRC is predicted to rise by 60% by 2030. Environmental factors drive, first, inflammation and hence, cancer incidence increase. MAIN: The Notch-signaling system is an evolutionarily conserved cascade, has role in the biological normal developmental processes as well as malignancies. Long non-coding RNAs (LncRNAs) have become major contributors in the advancement of cancer by serving as signal pathways regulators. They can control gene expression through post-translational changes, interactions with micro-RNAs or down-stream effector proteins. Recent emerging evidence has emphasized the role of lncRNAs in controlling Notch-signaling activity, regulating development of several cancers including CRC.
Notch-associated lncRNAs might be useful prognostic biomarkers or promising potential therapeutic targets for CRC treatment. Therefore, here-in we will focus on the role of "Notch-associated lncRNAs in CRC" highlighting "the impact of Notch-associated lncRNAs as player for cancer induction and/or progression."
结直肠癌（CRC）是最常见的消化系统癌症之一，在全球癌症相关死亡原因中排名第二。预计到2030年，全球结直肠癌负担将上升60%。环境因素首先引发炎症，进而导致癌症发病率增加。
Notch信号系统是一个进化上保守的级联反应，在生物正常发育过程以及恶性肿瘤中均发挥作用。长链非编码RNA（LncRNAs）通过作为信号通路调节因子，已成为癌症进展的主要促成因素。它们可以通过翻译后修饰、与微小RNA或下游效应蛋白相互作用来控制基因表达。最近新出现的证据强调了LncRNAs在控制Notch信号活性、调节包括结直肠癌在内的多种癌症发展中的作用。
Notch相关LncRNAs可能是有用的预后生物标志物或结直肠癌治疗中有前景的潜在治疗靶点。因此，在此我们将重点关注“Notch相关LncRNAs在结直肠癌中的作用”，突出“Notch相关LncRNAs作为癌症诱导和/或进展参与者的影响”。
