Alizadeh H, Castro G A, Weems W A
Gastroenterology. 1987 Oct;93(4):784-90. doi: 10.1016/0016-5085(87)90441-0.
The onset and duration of alterations in intrinsic fluid propelling behavior of guinea pig jejunum caused by infection with Trichinella spiralis was determined using an in vitro monitoring system. Isolated intestinal segments from uninfected hosts produced propulsive complexes of approximately 30-s duration at 125-s intervals. The maximum intraluminal pressure produced at the oral and aboral ends of the segments was approximately 25 cmH2O and the maximum rate of fluid ejection in both the oral and aboral directions was approximately 0.28 ml/s. Segments removed from guinea pigs 10 and 15 days after being inoculated with infective parasite larvae ejected significantly more fluid in the aboral as compared with the oral direction. The maximum aboral pressure developed 10 days postinoculation was 45.7 cmH2O and the maximum aboral fluid ejection rate was 0.60 ml/s. Analogous oral values were 29.0 cmH2O and 0.40 ml/s. This net aboral propulsion was not observed on days 7, 20, 30, or 60 postinoculation. We conclude that precise and highly predictable alterations in intrinsic propulsive behavior of the small intestine are induced by primary infection. These changes are expressed by day 10 postinoculation and are reversed upon spontaneous termination of the intestinal phase of parasitism.
利用体外监测系统确定了旋毛虫感染引起的豚鼠空肠内在液体推进行为改变的起始时间和持续时间。未感染宿主的离体肠段以125秒的间隔产生持续约30秒的推进复合体。肠段口端和肛端产生的最大腔内压力约为25 cmH₂O，口端和肛端的最大液体喷射速率约为0.28 ml/s。在接种感染性寄生虫幼虫10天和15天后从豚鼠身上取出的肠段，与口端方向相比，向肛端方向喷射的液体明显更多。接种后10天产生的最大肛端压力为45.7 cmH₂O，最大肛端液体喷射速率为0.60 ml/s。类似的口端数值分别为29.0 cmH₂O和0.40 ml/s。在接种后第7天、20天、30天或60天未观察到这种净肛端推进现象。我们得出结论，初次感染可诱导小肠内在推进行为发生精确且高度可预测的改变。这些变化在接种后第10天表现出来，并在寄生虫肠道阶段自然终止时逆转。
