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LINC01526通过与TARBP2相互作用诱导GNG7 mRNA降解促进胃癌的增殖和转移。

LINC01526 Promotes Proliferation and Metastasis of Gastric Cancer by Interacting with TARBP2 to Induce GNG7 mRNA Decay.

作者信息

Zhou Jin-Yong, Liu Jin-Yan, Tao Yu, Chen Chen, Liu Shen-Lin

机构信息

Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

Department of Breast and Thyroid Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China.

出版信息

Cancers (Basel). 2022 Oct 9;14(19):4940. doi: 10.3390/cancers14194940.

DOI:10.3390/cancers14194940
PMID:36230863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9562272/
Abstract

Gastric cancer is the most common malignancy of the human digestive system. Long noncoding RNAs (lncRNAs) influence the occurrence and development of gastric cancer in multiple ways. However, the function and mechanism of LINC01526 in gastric cancer remain unknown. Herein, we investigated the function of LINC01526 with respect to the malignant progression of gastric cancer. We found that LINC01526 was upregulated in gastric cancer cells and tissues. The function experiments in vitro and the Xenograft mouse model in vivo proved that LINC01526 could promote gastric cancer cell proliferation and migration. Furthermore, LINC01526 interacted with TAR (HIV-1) RNA-binding protein 2 (TARBP2) and decreased the mRNA stability of G protein gamma 7 (GNG7) through TARBP2. Finally, the rescue assay showed that downregulating GNG7 partially rescued the cell proliferation inhibited by LINC01526 or TARBP2 silencing. In summary, LINC01526 promoted gastric cancer progression by interacting with TARBP2, which subsequently degraded GNG7 mRNA. This study not only explores the role of LINC01526 in gastric cancer, but also provides a laboratory basis for its use as a new biomarker for diagnosis and therapeutic targets.

摘要

胃癌是人类消化系统最常见的恶性肿瘤。长链非编码RNA（lncRNAs）以多种方式影响胃癌的发生和发展。然而，LINC01526在胃癌中的功能和机制仍不清楚。在此，我们研究了LINC01526在胃癌恶性进展方面的功能。我们发现LINC01526在胃癌细胞和组织中上调。体外功能实验和体内异种移植小鼠模型证明LINC01526可促进胃癌细胞增殖和迁移。此外，LINC01526与HIV-1反式激活应答元件（TAR）RNA结合蛋白2（TARBP2）相互作用，并通过TARBP2降低G蛋白γ7（GNG7）的mRNA稳定性。最后，拯救实验表明下调GNG7可部分挽救由LINC01526或TARBP2沉默所抑制的细胞增殖。总之，LINC01526通过与TARBP2相互作用促进胃癌进展，随后TARBP2降解GNG7 mRNA。本研究不仅探讨了LINC01526在胃癌中的作用，还为其作为诊断新生物标志物和治疗靶点提供了实验依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/cb99379815f0/cancers-14-04940-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/b4b317fe8b67/cancers-14-04940-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/8178ddadea48/cancers-14-04940-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/57ee6609cbb9/cancers-14-04940-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/f795b33241cf/cancers-14-04940-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/4b6a9232e388/cancers-14-04940-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/8d2f46676dba/cancers-14-04940-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/cb99379815f0/cancers-14-04940-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/b4b317fe8b67/cancers-14-04940-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/8178ddadea48/cancers-14-04940-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/57ee6609cbb9/cancers-14-04940-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/f795b33241cf/cancers-14-04940-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/4b6a9232e388/cancers-14-04940-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/8d2f46676dba/cancers-14-04940-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0abf/9562272/cb99379815f0/cancers-14-04940-g007.jpg

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本文引用的文献

[1]
Long non-coding RNA promotes proliferation and migration of human gastric cancer cells HGC-27 via the human antigen R-F11R pathway.

J Int Med Res. 2022-4

[2]
BMI1 promotes osteosarcoma proliferation and metastasis by repressing the transcription of SIK1.

Cancer Cell Int. 2022-3-27

[3]
LINC00624/TEX10/NF-κB axis promotes proliferation and migration of human prostate cancer cells.

Biochem Biophys Res Commun. 2022-4-23

[4]
INTS7-ABCD3 Interaction Stimulates the Proliferation and Osteoblastic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Suppressing Oxidative Stress.

Front Physiol. 2021-11-22

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BMI1 promotes spermatogonia proliferation through epigenetic repression of Ptprm.

Biochem Biophys Res Commun. 2021-11-1

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ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.

Cell Death Dis. 2021-10-18

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Identification of circRNA-miRNA-mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer.

J Transl Med. 2021-5-28

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Bioengineered. 2021-12

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G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1.

Int J Biol Macromol. 2021-7-1

[10]
Long Noncoding RNA VESTAR Regulates Lymphangiogenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing VEGFC mRNA Stability.

Cancer Res. 2021-6-15

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