液液相分离在心血管疾病中的作用。
Liquid-Liquid Phase Separation in Cardiovascular Diseases.
机构信息
Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford Old Road, Headington, Oxford OX3 7LD, UK.
出版信息
Cells. 2022 Sep 28;11(19):3040. doi: 10.3390/cells11193040.
Liquid-liquid phase separation (LLPS) is a biochemical process in cells that can drive proteins, RNA, and other molecules to concentrate into droplets. These droplets do not have a lipid membrane but rather exist as distinct organelles relative to the surrounding environment, and act as biochemical reaction chambers. In recent years, significant progress has been made in the study of LLPS, especially in the neurodegenerative disease, cancer, and virology fields, but little is known about LLPS in cardiovascular disease (CVD). In this review, we discuss the current understanding of the mechanism and biological functions of LLPS, particularly its roles in regulating CVD.
液-液相分离（LLPS）是细胞中的一种生化过程，可促使蛋白质、RNA 和其他分子浓缩成液滴。这些液滴没有脂质膜，而是相对于周围环境存在的独特细胞器，并充当生化反应室。近年来，液-液相分离的研究取得了重大进展，特别是在神经退行性疾病、癌症和病毒学领域，但对心血管疾病（CVD）中的液-液相分离知之甚少。在这篇综述中，我们讨论了目前对液-液相分离的机制和生物学功能的理解，特别是它在调节 CVD 中的作用。
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