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[14C] - 三油酸甘油酯吸收试验:一种诊断吸收不良的有用检测方法。

[14C]-triolein absorption: a useful test in the diagnosis of malabsorption.

作者信息

Turner J M, Lawrence S, Fellows I W, Johnson I, Hill P G, Holmes G K

出版信息

Gut. 1987 Jun;28(6):694-700. doi: 10.1136/gut.28.6.694.

DOI:10.1136/gut.28.6.694
PMID:3623216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1433043/
Abstract

The [14C]-triolein absorption test has been assessed using a preprepared fat meal in a procedure that can be completed within a working day on an inpatient or outpatient basis. An initial study showed complete discrimination between 30 control subjects and 13 patients with raised faecal fat excretion. A prospective evaluation in 57 patients under investigation for gastrointestinal disease showed a sensitivity of 85% and specificity of 93% (100% if two obese subjects are excluded). The test discriminates satisfactorily between patients with and without fat malabsorption and makes the measurement of faecal fat unnecessary in most circumstances.

摘要

已使用预先准备好的脂肪餐对[14C]-三油酸甘油酯吸收试验进行了评估,该试验可在工作日内以住院或门诊方式完成。初步研究显示,30名对照受试者与13名粪便脂肪排泄增加的患者之间有完全的区分度。对57名正在接受胃肠道疾病调查的患者进行的前瞻性评估显示,敏感性为85%,特异性为93%(如果排除两名肥胖受试者,则为100%)。该试验能令人满意地区分有脂肪吸收不良和无脂肪吸收不良的患者,在大多数情况下无需测量粪便脂肪。

相似文献

1
[14C]-triolein absorption: a useful test in the diagnosis of malabsorption.[14C] - 三油酸甘油酯吸收试验:一种诊断吸收不良的有用检测方法。
Gut. 1987 Jun;28(6):694-700. doi: 10.1136/gut.28.6.694.
2
14C-triolein breath test as a rapid and convenient screening test for fat malabsorption.14C-三油酸甘油酯呼气试验作为脂肪吸收不良的快速便捷筛查试验。
Scand J Gastroenterol. 1983 Jan;18(1):9-12. doi: 10.3109/00365528309181550.
3
Radiotriolein revisited: a study of the 131 I-triolein absorption test using radiochemically pure triolein in man.放射性三油酸甘油酯再探讨:一项使用放射化学纯三油酸甘油酯对人体进行的131I-三油酸甘油酯吸收试验的研究。
J Nucl Med. 1972 Apr;13(4):252-9.
4
Combined single day 14C-triolein breath test and PABA test in the diagnosis of malabsorption.联合第14天单日14C-三油酸甘油酯呼气试验和对氨基苯甲酸试验诊断吸收不良。
Ann Clin Biochem. 1990 Jan;27 ( Pt 1):50-5. doi: 10.1177/000456329002700110.
5
Use of the triolein breath test for the demonstration of fat malabsorption in coeliac disease.使用三油酸甘油酯呼气试验来证实乳糜泻中的脂肪吸收不良。
Scand J Gastroenterol. 1984 May;19(3):307-14.
6
Simultaneous assessment of fat maldigestion and fat malabsorption by a double-isotope method using fecal radioactivity.采用粪便放射性双同位素法同时评估脂肪消化不良和脂肪吸收不良。
Gastroenterology. 1985 Jan;88(1 Pt 1):47-54. doi: 10.1016/s0016-5085(85)80131-1.
7
Triolein breath test of fat absorption in patients with chronic liver disease.慢性肝病患者脂肪吸收的三油酸甘油酯呼气试验
Dig Dis Sci. 1988 May;33(5):565-9. doi: 10.1007/BF01798358.
8
Serum radioactivity of 14C-triolein and 3H-oleic acid ingested in a test meal:a rapid test of pancreatic exocrine insufficiency.在试餐中摄入的14C-三油酸甘油酯和3H-油酸的血清放射性:胰腺外分泌功能不全的快速检测
Scand J Gastroenterol. 1979;14(5):529-34. doi: 10.3109/00365527909181385.
9
Estimation of 14C-triolein assimilation as a test of lipid assimilation. Breath test or measurement of serum radioactivity?将14C-三油酸甘油酯同化作为脂质同化试验进行评估。呼气试验还是血清放射性测量?
Scand J Gastroenterol. 1982 Mar;17(2):309-16. doi: 10.3109/00365528209182059.
10
Triolein breath test: a sensitive and specific test for fat malabsorption.
Gastroenterology. 1979 Jan;76(1):6-13.

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Guidelines for the investigation of chronic diarrhoea, 2nd edition.《慢性腹泻调查指南》第二版
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Butterfat absorption--a valuable screening test in malabsorption.乳脂肪吸收——一种用于吸收不良的重要筛查试验。
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Monitoring steatorrhoea in cystic fibrosis.
Eur J Pediatr. 1994 Jun;153(6):416-8. doi: 10.1007/BF01983404.
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Do we still need to measure faecal fat?我们仍然需要测量粪便脂肪吗?
Br Med J (Clin Res Ed). 1988 Jun 4;296(6636):1552-3. doi: 10.1136/bmj.296.6636.1552.
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14C triolein breath test: an assessment in the elderly.14C 三油酸甘油酯呼气试验:对老年人的一项评估
Gut. 1989 Aug;30(8):1082-6. doi: 10.1136/gut.30.8.1082.
7
Clinical monitoring of steatorrhoea in cystic fibrosis.囊性纤维化患者脂肪泻的临床监测
Arch Dis Child. 1990 Jan;65(1):99-102. doi: 10.1136/adc.65.1.99.

本文引用的文献

1
Screening for fat malabsorption.脂肪吸收不良的筛查。
Ann Intern Med. 1981 Dec;95(6):776-7. doi: 10.7326/0003-4819-95-6-776.
2
Estimation of 14C-triolein assimilation as a test of lipid assimilation. Breath test or measurement of serum radioactivity?将14C-三油酸甘油酯同化作为脂质同化试验进行评估。呼气试验还是血清放射性测量?
Scand J Gastroenterol. 1982 Mar;17(2):309-16. doi: 10.3109/00365528209182059.
3
Intestinal permeability in coeliac disease: the response to gluten withdrawal and single-dose gluten challenge.乳糜泻患者的肠道通透性:对麸质戒断和单剂量麸质激发试验的反应
Gut. 1982 Mar;23(3):202-10. doi: 10.1136/gut.23.3.202.
4
Comparison of simple screening tests for fat malabsorption.脂肪吸收不良简易筛查试验的比较
Br Med J (Clin Res Ed). 1981 May 9;282(6275):1501-4. doi: 10.1136/bmj.282.6275.1501.
5
Use of the triolein breath test for the demonstration of fat malabsorption in coeliac disease.使用三油酸甘油酯呼气试验来证实乳糜泻中的脂肪吸收不良。
Scand J Gastroenterol. 1984 May;19(3):307-14.
6
Is the 14C-triolein breath test useful in the assessment of malabsorption in clinical practice?在临床实践中,14C-三油酸甘油酯呼气试验对吸收不良的评估是否有用?
Digestion. 1984;29(2):91-7. doi: 10.1159/000199015.
7
14C-triolein breath test as a rapid and convenient screening test for fat malabsorption.14C-三油酸甘油酯呼气试验作为脂肪吸收不良的快速便捷筛查试验。
Scand J Gastroenterol. 1983 Jan;18(1):9-12. doi: 10.3109/00365528309181550.
8
Breath analysis: gastroenterological applications.呼吸分析:胃肠病学应用
Gastroenterology. 1974 Dec;67(6):1250-6.
9
Triolein breath test: a sensitive and specific test for fat malabsorption.
Gastroenterology. 1979 Jan;76(1):6-13.
10
Abnormal intestinal permeability to sugars in villous atrophy.绒毛萎缩时肠道对糖的通透性异常。
Lancet. 1979 Nov 24;2(8152):1107-9. doi: 10.1016/s0140-6736(79)92507-8.