West P S, Levin G E, Griffin G E, Maxwell J D
Br Med J (Clin Res Ed). 1981 May 9;282(6275):1501-4. doi: 10.1136/bmj.282.6275.1501.
Three tests were evaluated as screening procedures for fat malabsorption--namely, measurement of serum optical density, serum triglyceride concentration, and 14CO2 breath excretion after the administration of a 60 g fat meal containing 10 muCi glycerol tri[1-14C]oleate. The results of these tests were compared with fat excreted in a three-day faecal collection after adjustment for completeness of collection as assessed by using non-absorbable radio-opaque markers. Fifty-two patients with various symptoms and eight normal subjects were studied. The maximum increase in serum optical density or triglyceride concentration above the fasting value discriminated poorly between subjects with normal and increased adjusted faecal fat excretion. In contrast, seven- or eight-hour cumulative 14CO2 breath excretion provided good discrimination with only four (7%) false-positive and no false-negative results. The simplicity and convenience of breath analysis make it an attractive alternative to analysis of faecal fat excretion in screening for fat malabsorption.
对三项检测作为脂肪吸收不良的筛查程序进行了评估，即测量血清光密度、血清甘油三酯浓度，以及在给予含10微居里甘油三[1-14C]油酸酯的60克脂肪餐之后的14CO2呼气排泄量。将这些检测结果与在使用不可吸收的不透X线标记物评估收集完整性之后的三天粪便收集物中排出的脂肪进行比较。研究了52例有各种症状的患者和8名正常受试者。血清光密度或甘油三酯浓度高于空腹值的最大增加值，在调整粪便脂肪排泄正常和增加的受试者之间鉴别能力较差。相比之下，7或8小时的累积14CO2呼气排泄提供了良好的鉴别能力，仅有4例（7%）假阳性结果，且无假阴性结果。呼气分析的简单性和便利性使其成为筛查脂肪吸收不良时粪便脂肪排泄分析的一个有吸引力的替代方法。
