Nagabhushan M, Amonkar A J, Bhide S V
Food Chem Toxicol. 1987 Jul;25(7):545-7. doi: 10.1016/0278-6915(87)90207-9.
The effects of curcumin, the yellow pigment of the spice, turmeric (Curcuma longa) on the mutagenicity of several environmental mutagens were investigated in the Salmonella/microsome test with or without Aroclor 1254-induced rat-liver homogenate (S-9 mix). With Salmonella typhimurium strain TA98 in the presence of S-9 mix, curcumin inhibited the mutagenicity of bidi and cigarette smoke condensates, tobacco and masheri extracts, benzo[a]pyrne and dimethyl benzo[a]anthracene in a dose-dependent manner. Curcumin did not influence the mutagenicity without S-9 mix of sodium azide, monoacetylhydrazine and streptozocin in strain TA100 nor of 4-nitrophenylenediamine in strain TA98. Our observations indicate that curcumin may alter the metabolic activation and detoxification of mutagens.
在沙门氏菌/微粒体试验中，使用或不使用艾氏剂1254诱导的大鼠肝匀浆（S-9混合物），研究了姜黄（Curcuma longa）中的黄色色素姜黄素对几种环境诱变剂诱变性的影响。在存在S-9混合物的情况下，对于鼠伤寒沙门氏菌TA98菌株，姜黄素以剂量依赖性方式抑制了比迪烟和香烟烟雾浓缩物、烟草和马谢里提取物、苯并[a]芘和二甲基苯并[a]蒽的诱变性。在TA100菌株中，没有S-9混合物时，姜黄素不影响叠氮化钠、单乙酰肼和链脲佐菌素的诱变性；在TA98菌株中，也不影响4-硝基苯二胺的诱变性。我们的观察结果表明，姜黄素可能会改变诱变剂的代谢活化和解毒作用。
