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一种新型的锌（II）-原卟啉-壳聚糖-多壁碳纳米管纳米复合材料及其在咖啡酸传感中的应用。

A Novel Nanocomposite of Zn(II)-Protoporphyrin-Chitosan-Multi Walled Carbon Nanotubes and the Application to Caffeic Acid Sensing.

作者信息

Han Bingkai, Wen Xin, Wang Jinneng, Sun Yingrui

机构信息

Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, College of Exercise Health, Tianjin University of Sport, No. 16 Donghai Road, West Tuanbo New Town, Jinghai District, Tianjin 301617, China.

The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Weijin Road No. 94, Tianjin 300071, China.

出版信息

Nanomaterials (Basel). 2022 Sep 29;12(19):3412. doi: 10.3390/nano12193412.

DOI:10.3390/nano12193412
PMID:36234540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9565613/
Abstract

Caffeic acid is an antioxidant that has been widely been related to the health benefits of people in recent years. In this paper, the amino side chains of chitosan (CS) were modified with protoporphyrin IX by amide cross-linking, and then Zn ions were chelated. The properties of metalloporphyrin-preparing functionalized multi-walled carbon nanotubes (MWCNTs) and Zn ions chelated by protoporphyrin IX composites were used as sensitive-selective electrochemical biosensors for the determination of caffeic acid. The morphology and structure of nanocomposite Zn-PPIX-CS-MWCNTs were observed by X-ray spectroscopy mapping (EDX mapping), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR). The electrochemical behaviors of Zn-PPIX-CS-MWCNT-modified glassy carbon (GC) electrodes were evaluated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results show that the modified electrode had good electrocatalytic activity towards caffeic acid with a wide linear range of 0.0008-1.6 mM, an excellent sensitivity of 886.90 µAmMcm, and a detection limit of 0.022 µM. In addition, the caffeic acid sensor had excellent reproducibility, stability, and selectivity to various interfering substances. Therefore, the modified electrode prepared by this experiment can also be applied to electrochemical sensors of other substances.

摘要

咖啡酸是一种抗氧化剂，近年来人们发现它对健康有益。本文通过酰胺交联用原卟啉IX修饰壳聚糖（CS）的氨基侧链，然后螯合锌离子。以制备金属卟啉的功能化多壁碳纳米管（MWCNTs）和原卟啉IX复合材料螯合的锌离子的性能作为灵敏选择性电化学生物传感器用于测定咖啡酸。通过X射线光谱映射（EDX映射）、透射电子显微镜（TEM）和傅里叶变换红外光谱（FTIR）观察了纳米复合材料Zn-PPIX-CS-MWCNTs的形态和结构。通过循环伏安法（CV）和差分脉冲伏安法（DPV）评估了Zn-PPIX-CS-MWCNT修饰玻碳（GC）电极的电化学行为。结果表明，修饰电极对咖啡酸具有良好的电催化活性，线性范围宽，为0.0008 - 1.6 mM，灵敏度优异，为886.90 µAmMcm，检测限为0.022 µM。此外，咖啡酸传感器对各种干扰物质具有优异的重现性、稳定性和选择性。因此，本实验制备的修饰电极也可应用于其他物质的电化学传感器。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/b70ccac5cca1/nanomaterials-12-03412-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/0135fcfeb034/nanomaterials-12-03412-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/3146a89d0f13/nanomaterials-12-03412-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/de8ab6b7a90b/nanomaterials-12-03412-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/9d3c050a669a/nanomaterials-12-03412-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/551d1f8bfff1/nanomaterials-12-03412-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/8c3785acc55f/nanomaterials-12-03412-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/ba4f6298b02f/nanomaterials-12-03412-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/b70ccac5cca1/nanomaterials-12-03412-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/0135fcfeb034/nanomaterials-12-03412-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/3146a89d0f13/nanomaterials-12-03412-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/de8ab6b7a90b/nanomaterials-12-03412-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/9d3c050a669a/nanomaterials-12-03412-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/551d1f8bfff1/nanomaterials-12-03412-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/8c3785acc55f/nanomaterials-12-03412-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/ba4f6298b02f/nanomaterials-12-03412-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edcb/9565613/b70ccac5cca1/nanomaterials-12-03412-g007.jpg

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