: 从澳大利亚本土植物中分离出的一种新型抗炎化合物。
: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant .
机构信息
NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.
Department of Pharmacology, Western Sydney University, Campbelltown Campus, Sydney, NSW 2560, Australia.
出版信息
Molecules. 2022 Oct 5;27(19):6592. doi: 10.3390/molecules27196592.
Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of which led to the discovery of a new anti-inflammatory compound, tristaenone A (). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A () suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC values of 37.58 ± 2.45 μM, 80.6 ± 5.82 μM and 125.65 ± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 ± 14.14% at a concentration of 31.85 μM.
受民族药理学知识的启发，我们对 的叶子进行了生物活性导向分离，发现了一种新的抗炎化合物，三烯酮 A（）。通过详细的光谱数据分析阐明了其结构，并通过 X 射线晶体学分析确定了其绝对构型。三烯酮 A（）对 LPS 和 IFN-γ诱导的 RAW 264.7 细胞中 NO、TNF-α 和 IL-6 的产生具有抑制作用，IC 值分别为 37.58±2.45μM、80.6±5.82μM 和 125.65±0.34μM。它还在 31.85μM 的浓度下抑制 NF-κB 核易位达 52.93±14.14%。
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