Myrtinols A-F: New Anti-Inflammatory Peltogynoid Flavonoid Derivatives from the Leaves of Australian Indigenous Plant .

Our in-house ethnopharmacological knowledge directed our anti-inflammatory investigation into the leaves of . Bioassay guided isolation of the Australian indigenous plant led to the isolation of six new rare peltogynoid derivatives named myrtinols A-F (-) along with three known compounds 4--methylcedrusin (), 7--methylcedrusin () and 8-demethylsideroxylin (). The chemical structures of all the compounds were elucidated by detailed spectroscopic data analysis, and absolute configuration was established using X-ray crystallography analysis. All compounds were evaluated for their anti-inflammatory activity by assessing the inhibition of nitric oxide (NO) production and tumor necrosis factor- α (TNF-α) in lipopolysaccharide (LPS) and interferon (IFN)-γ activated RAW 264.7 macrophages. A structure activity relationship was also established between compounds (-), noting promising anti-inflammatory potential by compounds and with an IC value of 8.51 ± 0.47 and 8.30 ± 0.96 µg/mL for NO inhibition and 17.21 ± 0.22 and 46.79 ± 5.87 µg/mL for TNF-α inhibition, respectively.