Bernier Emilie, Plante Anne-Sophie, Robitaille Julie, Lemieux Simone, Girard Mario, Bujold Emmanuel, Gagnon Claudia, Weisnagel S John, Tchernof André, Morisset Anne-Sophie
School of Nutrition, Université Laval, Québec, Canada.
NUTRISS Centre - Nutrition, Health and Society, Institute of Nutrition and Functional Foods, Université Laval, Québec, Canada.
Int J Food Sci Nutr. 2023 Mar;74(2):268-278. doi: 10.1080/09637486.2023.2171371. Epub 2023 Jan 29.
We aimed to characterise the associations between first-trimester diet quality, adiposity, and glucose homeostasis measurements throughout pregnancy in a sample of 104 healthy pregnant women. Three Web-based 24-h recalls were completed, from which the Alternate Healthy Eating Index (AHEI) was calculated. At each trimester (12.5 ± 0.7, 22.8 ± 1.0, and 33.6 ± 1.3 weeks of gestation), fasting glucose and insulin were measured to compute an insulin resistance index (HOMA-IR). Subcutaneous and visceral adipose tissue thicknesses were estimated by ultrasound at the end of the first trimester. Inverse associations were observed between the first-trimester AHEI and first-trimester fasting insulin (0.24; < 0.05), and HOMA-IR ( = -0.22; < 0.05), as well as third-trimester fasting insulin ( = -0.20; < 0.05). A trend was also observed between first-trimester AHEI and first-trimester SAT thickness ( = -0.17; < 0.1). Pre- and early-pregnancy adiposity measurements were identified as high predictors fasting insulin concentrations throughout pregnancy. Higher early-pregnancy diet quality is associated with more favourable metabolic measurements during pregnancy.
我们旨在对104名健康孕妇样本在整个孕期的孕早期饮食质量、肥胖程度和葡萄糖稳态测量之间的关联进行特征描述。完成了三次基于网络的24小时饮食回顾，据此计算替代健康饮食指数（AHEI）。在每个孕期（妊娠12.5±0.7周、22.8±1.0周和33.6±1.3周），测量空腹血糖和胰岛素以计算胰岛素抵抗指数（HOMA-IR）。在孕早期结束时通过超声估计皮下和内脏脂肪组织厚度。观察到孕早期AHEI与孕早期空腹胰岛素（β = 0.24；P < 0.05）、HOMA-IR（β = -0.22；P < 0.05）以及孕晚期空腹胰岛素（β = -0.20；P < 0.05）之间呈负相关。在孕早期AHEI与孕早期皮下脂肪厚度之间也观察到一种趋势（β = -0.17；P < 0.1）。孕前期和孕早期的肥胖测量被确定为整个孕期空腹胰岛素浓度的高预测指标。孕早期更高的饮食质量与孕期更有利的代谢测量结果相关。
