消化系统癌症肿瘤微环境中环型 RNA 失调的机制。

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Front Immunol. 2022 Sep 27;13:951561. doi: 10.3389/fimmu.2022.951561. eCollection 2022.

Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been reported to be expressed in eukaryotic cells and have a variety of biological functions in the regulation of cancer pathogenesis and progression. The TME, as a microscopic ecological environment, consists of a variety of cells, including tumor cells, immune cells and other normal cells, ECM and a large number of signaling molecules. The crosstalk between circRNAs and the TME plays a complicated role in affecting the malignant behaviors of digestive system cancers. Herein, we summarize the mechanisms underlying aberrant circRNA expression in the TME of the digestive system cancers, including immune surveillance, angiogenesis, EMT, and ECM remodelling. The regulation of the TME by circRNA is expected to be a new therapeutic method.

环状 RNA（circRNAs）是一类新的非编码 RNA（ncRNAs），已被报道在真核细胞中表达，并在调控癌症发病机制和进展方面具有多种生物学功能。TME 作为一种微观生态环境，由多种细胞组成，包括肿瘤细胞、免疫细胞和其他正常细胞、ECM 和大量信号分子。circRNAs 与 TME 之间的串扰在影响消化系统癌症的恶性行为方面起着复杂的作用。在此，我们总结了消化系统癌症 TME 中异常 circRNA 表达的机制，包括免疫监视、血管生成、EMT 和 ECM 重塑。circRNA 对 TME 的调节有望成为一种新的治疗方法。