环状RNA在膀胱癌发生中的作用
The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer.
作者信息
Ghafouri-Fard Soudeh, Najafi Sajad, Hussen Bashdar Mahmud, Basiri Abbas, Hidayat Hazha Jamal, Taheri Mohammad, Rashnoo Fariborz
机构信息
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Front Oncol. 2022 Feb 28;12:801842. doi: 10.3389/fonc.2022.801842. eCollection 2022.
Circular RNAs (circRNAs) are a group of transcripts with enclosed configurations which can regulate gene expression. These transcripts have important roles in normal development and in the pathogenesis of disorders. Recent evidence has supported involvement of circRNAs in the development of bladder cancer. Several circRNAs such as circ_0058063, hsa-circRNA-403658, circPDSS1, circCASC15, circRNA-MYLK, and circRNA_103809 have been upregulated in bladder cancer samples. On the other hand, hsa_circ_0137606, BCRC-3, circFUT8, hsa_circ_001598, circSLC8A1, hsa_circ_0077837, hsa_circ_0004826, and circACVR2A are among downregulated circRNAs in bladder cancer. Numerous circRNAs have diagnostic or prognostic value in bladder cancer. In this review, we aim to outline the latest findings about the role of circRNAs in bladder cancer and introduce circRNAs for further investigations as therapeutic targets.
环状RNA（circRNAs）是一类具有封闭结构的转录本，可调控基因表达。这些转录本在正常发育和疾病发病机制中发挥重要作用。最近的证据支持环状RNA参与膀胱癌的发生发展。在膀胱癌样本中，几种环状RNA如circ_0058063、hsa-circRNA-403658、circPDSS1、circCASC15、circRNA-MYLK和circRNA_103809已上调。另一方面，hsa_circ_0137606、BCRC-3、circFUT8、hsa_circ_001598、circSLC8A1、hsa_circ_0077837、hsa_circ_0004826和circACVR2A是膀胱癌中下调的环状RNA。众多环状RNA在膀胱癌中具有诊断或预后价值。在本综述中，我们旨在概述关于环状RNA在膀胱癌中作用的最新发现，并介绍环状RNA作为治疗靶点以供进一步研究。
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