Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan, 250061, P. R. China.
Key National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan, 250061, P. R. China.
Macromol Biosci. 2023 Jan;23(1):e2200235. doi: 10.1002/mabi.202200235. Epub 2022 Oct 21.
Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process. Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application. In this work, biodegradable hydrogels containing herbal extracts are prepared for wound dressings. First, the active ingredients are extracted from Amaranthus spinosus (A. spinosus) and Rubia cordifolia (R. cordifolia) and added to the hydrogels prepared from microcrystalline cellulose (MCC), carrageenan, and sodium alginate. Then the composite hydrogels are air-dried to obtain the wound dressings. The wound dressings prepared in this work have good biocompatibility and moisture retention. The mechanical properties of the wound dressings are further improved with the addition of MCC. Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract. Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth. The wound dressings perform well in the animal wound models to promote wound healing. These results indicate that the hydrogel wound dressings prepared in this work have great potential for medical applications.
加速凝血过程和预防伤口感染是伤口护理过程中的主要挑战。因此，具有促凝血、抗菌和抗氧化特性的新型多功能伤口敷料具有巨大的临床应用潜力。在这项工作中，制备了含有草药提取物的可生物降解水凝胶作为伤口敷料。首先，从刺苋菜（A. spinosus）和茜草（R. cordifolia）中提取活性成分，并将其添加到由微晶纤维素（MCC）、卡拉胶和海藻酸钠制备的水凝胶中。然后将复合水凝胶风干得到伤口敷料。本工作制备的伤口敷料具有良好的生物相容性和保湿性。通过添加 MCC，进一步提高了伤口敷料的机械性能。此外，由于含有茜草提取物，伤口敷料具有优异的促凝血、抗菌和抗氧化性能。总的来说，不同配方成分的最有效组伤口敷料能将凝血时间缩短 75%，并能在很大程度上抑制细菌生长。伤口敷料在动物伤口模型中表现良好，能促进伤口愈合。这些结果表明，本工作制备的水凝胶伤口敷料在医学应用方面具有巨大的潜力。
