School of Energy and Materials, Shanghai Key Laboratory of Engineering Materials Application and Evaluation, Shanghai Polytechnic University, Shanghai 201209, China.
Department of Endocrinology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Int J Biol Macromol. 2023 Jun 15;240:124321. doi: 10.1016/j.ijbiomac.2023.124321. Epub 2023 Apr 4.
Wound healing is a complex project, and effectively promoting skin repair is a huge clinical challenge. Hydrogels have great prospect in the field of wound dressings because their physical properties are very similar to those of living tissue and have excellent properties such as high water content, oxygen permeability and softness. However, the single performance of traditional hydrogels limits their application as wound dressings. Therefore, natural polymers such as chitosan, alginate and hyaluronic acid, which are non-toxic and biocompatible, are individually or combined with other polymer materials, and loaded with typical drugs, bioactive molecules or nanomaterials. Then, the development of novel multifunctional hydrogel dressings with good antibacterial, self-healing, injectable and multi-stimulation responsiveness by using advanced technologies such as 3D printing, electrospinning and stem cell therapy has become a hot topic of current research. This paper focuses on the functional properties of novel multifunctional hydrogel dressings such as chitosan, alginate and hyaluronic acid, which lays the foundation for the research of novel hydrogel dressings with better performance.
创伤愈合是一个复杂的过程，有效地促进皮肤修复是一个巨大的临床挑战。水凝胶在创伤敷料领域具有广阔的前景，因为其物理性质与活组织非常相似，具有高含水量、氧气透过性和柔软性等优异性能。然而，传统水凝胶的单一性能限制了其作为创伤敷料的应用。因此，壳聚糖、海藻酸盐和透明质酸等天然聚合物具有无毒、生物相容性，可单独或与其他聚合物材料结合，并负载典型药物、生物活性分子或纳米材料。然后，通过 3D 打印、静电纺丝和干细胞治疗等先进技术，开发具有良好抗菌、自修复、可注射和多重刺激响应的新型多功能水凝胶敷料，已成为当前研究的热点。本文重点介绍了壳聚糖、海藻酸盐和透明质酸等新型多功能水凝胶敷料的功能特性，为研究性能更好的新型水凝胶敷料奠定了基础。
