限时进食和减肥对骨代谢和健康的影响：一项为期 6 个月的随机对照试验。
The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.
机构信息
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Nutrition Unit, Service of Endocrinology, Diabetes, Nutrition and Therapeutic Education, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
出版信息
Obesity (Silver Spring). 2023 Feb;31 Suppl 1(Suppl 1):85-95. doi: 10.1002/oby.23577. Epub 2022 Oct 14.
OBJECTIVE
This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.
METHODS
Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response.
RESULTS
In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes.
CONCLUSIONS
TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.
目的
本研究探讨限时进食（TRE）与标准饮食建议（SDA）对骨骼健康的影响。
方法
患有≥1 项代谢综合征成分的成年人被随机分为 TRE（12 小时内随意进食）或 SDA（食物金字塔手册）组。基线和 6 个月随访时，通过双能 X 射线吸收法评估骨转换标志物和骨矿物质含量/密度。在总人群和体重减轻反应人群中进行统计分析。
结果
在总人群（n=42，76%为女性，中位年龄 47 岁[IQR：31-52]）中，任何骨参数在 TRE 组与 SDA 组之间均无差异。在体重减轻反应者（≥0.6 kg 体重减轻）中，TRE 后 I 型胶原羧基末端肽β降解标志物β-CTX 倾向于降低，而 SDA 后则增加（组间差异 p=0.041），而骨形成标志物 I 型前胶原 N 端肽的变化在两组之间无差异。在体重减轻反应者中，SDA 后全身骨矿物质含量降低（p=0.028），而 TRE 后则保持不变（p=0.31）（组间差异 p=0.028）。在无反应者（<0.6 kg 体重减轻）中，两组之间的骨结局无差异。
结论
TRE 对骨骼健康没有不良影响，而当体重减轻发生时，与 SDA 相比，它与一些骨保护作用相关。
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