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肠道微生物群与过敏性鼻炎;重新关注益生菌作为一种治疗选择的作用。

The gut microbiome and allergic rhinitis; refocusing on the role of probiotics as a treatment option.

作者信息

Li Jianghua, Fang Fang, Mei Mei, Wu Dongmei

机构信息

School of Basic Medicine, Jiamusi University, Jiamusi, 154007, China.

E.N.T. Department, The First Affiliated Hospital of Jiamusi University, Jiamusi, 154007, China.

出版信息

Eur Arch Otorhinolaryngol. 2023 Feb;280(2):511-517. doi: 10.1007/s00405-022-07694-z. Epub 2022 Oct 14.

Abstract

INTRODUCTION

In the industrialized world, the incidence of Allergic rhinitis (AR), often known as hay fever, and other allergic disorders continues to grow. Recent studies have suggested environmental variables such as bacterial exposures as a potential reason for the rising prevalence of AR. With breakthroughs in our abilities to research the complex crosstalk of bacteria, the gut microbiomes' effect on human development, nutritional requirements, and immunologic disorders has become apparent METHODS: Three search engines, including Scopus, Medline, and PubMed, were searched for related published articles up to and including 1st July 2022.

RESULTS

Several studies have investigated links between commensal microbiome alterations and the development of atopic diseases such as asthma and AR. Besides, studies using probiotics for treating AR suggest that they may alleviate symptoms and improve patient's quality of life.

CONCLUSION

Research on probiotics and synbiotics for AR suggests they may improve symptoms, quality of life, and laboratory indicators. A better treatment strategy with advantages for patients may be achieved using probiotics, but only if more detailed in vitro and in vivo investigations are conducted with more participants.

摘要

引言

在工业化世界,过敏性鼻炎(AR),通常称为花粉热,以及其他过敏性疾病的发病率持续上升。最近的研究表明,诸如接触细菌等环境变量是AR患病率上升的一个潜在原因。随着我们研究细菌复杂相互作用能力的突破,肠道微生物群对人类发育、营养需求和免疫紊乱的影响已变得明显。方法:检索了三个搜索引擎,包括Scopus、Medline和PubMed,以查找截至2022年7月1日(含该日)发表的相关文章。

结果

多项研究调查了共生微生物群改变与哮喘和AR等特应性疾病发展之间的联系。此外,使用益生菌治疗AR的研究表明,它们可能减轻症状并改善患者的生活质量。

结论

对AR使用益生菌和合生元的研究表明,它们可能改善症状、生活质量和实验室指标。只有对更多参与者进行更详细的体外和体内研究,使用益生菌才可能实现对患者有利的更好治疗策略。

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